Preparation And Application Of Multifunctional Inorganic Nanoparticles Using Poly (Acrylic Acid) Sodium As Template

Multifunctional inorganic nanoparticles with mesoporous or hollow structure,have been widely used in many bio-related fields due to its unique properties and potential biological applications.On the one hand,inorganic nanoparticles have unique advantages as drug carriers,including its good stability and biocompatibility as well as the mild preparation conditions.On the other hand,hollow nanoparticles with mesoporous in their shells have potential applications in sensing and catalysis,drug storage and delivery owing to its unique structures.Generally,the major applications of inorganic mesoporous nanoparticles in the biomedical field are cancer imaging and therapy.In recent years,the fabrication of inorganic mesoporous nanoparticles combining distinct fluorescent and magnetic as well as drug delivery properties in a single unit have been receiving great attention.In this thesis,we developed a novel and facile method to obtain PAA/CaCO₃ mesoporous nanoparticles and Eu³⁺ doped Gd₂O₃ hollow mesoporous nanoparticles?HMNPs?by using poly?acrylic acid?sodium as template which have good dispersion and stability.The obtained PAA/CaCO₃ nanoparticles show ultrahigh DOX loading capacity and pH-response sustained release properties.Moreover,the PAA/CaCO₃ nanoparticles possess excellent biocompatibility and show exceptional antitumor effects without any toxicity in vitro and in vivo.The prepared Eu³⁺-doped Gd₂O₃ HMNPs exhibit excellent fluorescence and magnetic properties due to the existence of Gd₂O₃ and Eu³⁺.In addition,owing to the hollow mesoporous structure,the obtained HMNPs possess high drug loading capacity and sustained release property.Therefore,the resulting HMNPS can be used as nanoprobes and drug carriers for simultaneous cancer diagnosis and therapy.