Study On The Preparation And Properties Of Dextran Linkage Polymer Antitumor Drugs Carriers

Cancer is one of the deadliest diseases and is a major threat to human health.In the current cancer treatment,chemotherapy plays an important role in anti-cancer.However,conventional chemotherapy using free anticancer drugs has various limitations such as poor water solubility,selective non-specificity,low local therapeutic concentration,and adverse side effects on normal cells.To address these limitations,studies have found that some nanocarriers can selectively deliver drugs to specific locations in the organism.With these nanocarriers,drugs can be delivered to cancer cells,thereby reducing toxic side effects and releasing drugs in a controlled manner.However,most drug carriers are designed for hydrophobic molecules,in which the drug is embedded in a hydrophobic matrix;when the hydrophobic matrix is too large,the solubility of the drug carrier decreases,and when the hydrophobic substrate is too low,it is not conducive to Embedding.In this dissertation,dextran was used as the main chain to solve this problem.The drug carrier as a hydrophilic matrix directly carries anticancer drugs,which completely solves the problem of low solubility.A p H-sensitive traceable dextran-hydroxyphenylboronic acid-Dr-PBA-Rh B polymer was prepared by introducing an acid-labile boron ester bond in the dextran backbone;A p H-sensitive,drug-loaded Dex-PBA-Mustard polymer was prepared by introducing an acid-labile boron ester linkage in the chain;the acid was introduced into the glucan backbone Unstable boron ester linkages prepare p H-sensitive,targeted,tracer,drug-loaded carboxyphenylboronic acid-dextran-(cadmium telluride)-hydroxy-phenylboronic acid-phenylbutyrate mustard(PBA-Dex-(Cd Te)-PBA-Mustard)poly-mer.The main content of this paper includes the following aspects:(1)Dex-PBA-Rh BPreparation of tumor tracers.Drugs are: 3-hydroxyphenylboronic acid,Rhodami-ne B.Rhodamine B as a tracer.Dextran serves as a skeleton.The above drugs are polymerized to obtain a polymer that is released in vitro to verify the acid hydrolysis effect of the boron ester bond in the polymer.The material synthesized by nuclear magnetic resonance H-spectroscopy was characterized.(2)Dex-PBA-MustardPassively targeted anticancer drug preparation.Drugs are: 3-Hydroxyphenylboro-nic acid,chlorambucil.The above drugs and dextran are polymerized to obtain a macromolecular anticancer drug.Cell experiments verify the anticancer effect of the polymer.The material synthesized by nuclear magnetic resonance H-spectroscopy was characterized.(3)PBA-Dex-(Cd Te)-PBA-MustardActively targeted,nuclear-trapping drug preparation.Drugs are: 3-hydroxypheny-lboronic acid,4-carboxyphenylboronic acid,chlorambucil,cadmium telluride(Cd Te)quantum dots.Cadmium telluride as a tracer.4-Carboxyphenylboronic acid was used as a targeted drug and dextran was used as a scaffold.The above-mentioned drugs are polymerized to obtain a polymer.After the polymer reacts with cadmium telluride,it is a tumor diagnostic imaging agent.Cellular experiments were used to verify polymer targeting.The material synthesized by nuclear magnetic resonance H-spectro-scopy was characterized.