Research On The Effects Of Taurine On The Lifespan Of Drosophila

Aging refers to the process of various problems in an organism over time.Dietary restriction,interventional signaling pathways or certain response processes(TOR,glycolysis,GH/IGF-1,Sirtuin protein,AMPK,inflammatory response,epigenetic signaling pathways or reaction processes)are common avenues of anti-aging.Taurine is a common food additive.It is rich in human body and participates in many physiological processes of the human body,including lipid metabolism,energy consumption,inhibition of oxidative stress and inflammation,maintenance of calcium ion balance,regulation.Osmotic pressure,stability of cell membrane,growth of skeletal muscle,protection of nerves,etc.By studying different concentrations of taurine to raise two genotypes of Drosophila melanogaster(W1118,Canton-S),observe the effect of taurine on life,food intake and anti-stress ability(high temperature,high oxygen,hunger),reproductive capacity,activity and sleep,antioxidant capacity,etc.to explore the regulation of taurine on the lifespan of Drosophila.The results show:Taurine can prolong life at some concentrations,and some concentrations can shorten the lifespan of fruit flies,which is not achieved by limiting diet.On die fertility effects of Drosophila,taurine can inhibit the egg laying of Drosophila regardless of W1118 and Canton-S.On the effects of activity and sleep,taurine can reduce activity and improve sleep time,and this effect as the age increases,the effect becomes more apparent.For high concentrations of taurine,the lifespan of fruit flies can be significantly shortened.Finally,taurine has little effect on the anti-stress ability of Drosophila,and has no effect on antioxidant capacity.The above studies provide taurine as a food additive and its reference as a potential anti-aging drug.