Synthesis Of Primary Amines And Alcohol Compounds Using Palladium Catalyst Under Mild Conditions

In this thesis,the author has developed three different methods for synthesis of primary amines,and developed a new method for synthesis of alcohols.(1)The nitrile compound as a substrate,using palladium nano-catalyst to synthesize a primary amine in a normal temperature(1 atm H2)and aqueous phase.(2)The oxime compound as a substrate,using palladium nano-catalyst to synthesize a primary amine in a normal temperature(1 atm H2)and aqueous phase.(3)The nitro-compound as a substrate,using palladium nano-catalyst to synthesize a primary amine in a normal temperature(1 atm H2)and aqueous phase.(4)The aldehyde/ketone compound as a substrate,using palladium nano-catalyst to synthesize an alcohol in a normal temperature(1 atm H2)and aqueous phase.Different palladium nano-catalysts were obtained by different ligands.In the above methods(1)and(2),the reaction conditions were optimized,and a palladium nano-catalyst was finally determined,and the optimal reaction conditions were obtained.The catalyst was determined by EA,ICP-OES,HRTEM,XRD,XPS and1H NMR solid spectrum.For the above methods,the substrate was expanded,and most of the substrates were reduced to the corresponding products,indicating that the catalyst has high selectivity.When the catalyst was used,and the substrate contains halogen(except F atom),the halogen atom is replaced by a hydrogen atom during the hydrogenation reduction process.For the palladium nano-catalyst,a recycling experiment was carried out,and it was found that the catalyst used for 10 times still has high catalytic activity and stability.In the above four methods:the amount of the substrate is 0.05 mmol,the catalyst loading is 4 mol%,the reaction temperature is room temperature,the pressure of hydrogen is 1 atm,and the water is 10 mL.The isolation product is characterized by1H NMR,13C NMR and HRMS spectral data.