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Study On The Synthesis Of Several Key Pharmaceutical Intermediates

Posted on:2019-06-05Degree:MasterType:Thesis
Country:ChinaCandidate:Y ZhangFull Text:PDF
GTID:2381330572996041Subject:Applied Chemistry
Abstract/Summary:PDF Full Text Request
Cancer has become a major disease that poses a serious threat to human health and social development.Lung cancer and breast cancer are especially malignant tumors with a very high incidence rate.Targeted drug therapy is an emerging treatment method that can specifically attack tumor cells and has the advantages of low toxicity and side effects.It is one of the most important methods for cancer treatment at present.In recent years,various new targeted drugs have been introduced.gefitinib is used to treat patients with advanced non-small cell lung cancer and palbociclib is used to treat breast cancer patients.The development of gefitinib and palbociclib and its intermediates has a good market prospect.In this dissertation,gefitinib and palbociclib were selected as the research object,and the synthesis routes of several key intermediates of these two drugs were optimized.The thesis was divided into the following sections:The first chapter summarizes the development and harm of cancer,current treatments,and specific introductions to gefitinib and palbociclib.In the second chapter,the optimization of the synthesis process of key nucleus intermediates for gefitinib was carried out,and the best reaction conditions were obtained.The structure and purity of the intermediates were discussed and analyzed.The third chapter optimizes the synthetic process of the key intermediates of palbociclib and obtains the conditions of low raw material cost and suitable for industrial production.The structure and purity of the intermediates were discussed and analyzed.The fourth chapter optimizes the synthetic process of palbociclib side chain intermediates.By improving post-processing methods,we obtains high-quality intermediates with high purity and low content of various impurities.Simultaneously,the process operation is simple and it is suitable for the industrial production.
Keywords/Search Tags:targeted therapy, gefitinib, pabificib, pharmaceutical intermediates, organic synthesis
PDF Full Text Request
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