Synthesis Of A Series Of Water-Soluble Anthrancene Sulfonated Crown Ether And Its Host-Guest Bonding And Supramolecular Assembly

In the long history of supramolecular chemistry,it is the main task and the core competence of supramolecular chemistry to study the force of noncovalent bonds between molecules.Crown ethers,as the first generation of macrocyclic main compounds,have been in the research boom and abundant research results are countless.So far,crown ether has been studied in many directions,but the modified water-soluble sulfonated crown ether,especially the water-soluble sulfonated crown ether with negative charge,is an excellent macrocyclic main compound.It can not only bond between charged objects,but also selectively recognize ions.This property is widely used in ion selective recognition and protease simulation as well as other applications.Based on the theoretical support of supramolecular chemistry and intermolecular noncovalent bond force,several macrocyclic main compounds were synthesized,and the bond between several macrocyclic compounds and the guest was studied.In the first part,the concept of supramolecular chemistry and the force of noncovalent bonds between molecules are introduced.In the second part,two kinds of macrocyclic anthracene crown ethers with different tetrasulfonic acids were designed and synthesized,which solved the problem that anthracene crown ethers were difficult to synthesize.Moreover,the bond ability of macrocyclic crown ethers was compared with previous ones,and the relationship between the bond ability of several kinds of sulfonated crown ethers was obtained.In the third part,we mainly studied the anthracenaphthalene and crown ether of two kinds of disulfonic acid,the selective modification of anthracenaphthalene and crown ether,the synthesis of asymmetric crown ether structure,which is a difficult breakthrough point in crown ether chemistry.In the fourth part,sulfonated anthracene crown ether with dicarboxylic acid of disulfonate was designed and synthesized.Crown ether with sulfonate and carboxylic acid could significantly improve the fluorescence intensity of acridine orange by binding with acridine orange,which was regulatory and could be used as a potential new macrocyclic subject with regulatory properties.