Synthesis And Application Of Fluorescent Probes Based On Metal-Organic Framework Materials

Metal-Organic Framework（Metal-Organic Frameworks,MOFs）is a coordination compound with periodic structure which is combined by coordination bonds and uses organic ligands and metal ions or clusters as nodes.Due to the potential applications of MOFs materials in catalysis,gas adsorption and separation,drug delivery,sensing and so on,it has been developing rapidly in recent years.Among them,Nano Metal-Organic Framework Materials（NMOFs）have both the structural characteristics of traditional MOFs and the size effect of nano-materials,which makes them have a better performance.Built on the synthesis and application of MOFs fluorescent probes,the synthesis of self-assembled organic molecular sensors for UiO series MOFs is mainly based on the detection of molecules and intracellular active substances in life and fluorescence imaging.Organic molecular sensors（OMSs）and post-synthesis modifications（PSM）were put in place to introduce reactive sites.Ⅰ.UiO-68 fluorescent probe based on redox mechanism was synthesized by self-assembly of dicarboxylic acid ligands H₂L and Zr（Ⅳ）salt.It is unique to the detection of HClO.Under the premise of high sensitivity,it is physically mixed with polyvinyl alcohol（PVA）to form mixed matrix membranes（MMMs）,which are utilized to detect HClO content in tap water by visual color change.Ⅱ.Design and synthesis an UiO-68 NMOFs two-photon fluorescent probe based on fluorescent"turn-on"type were synthesized.Organic ligand of UiO-68 is linked to the classical two-photon group 4-bromo-1,8-naphthalimide,and the azide is modified by post-synthesis modification to achieve specificity to H2S.UiO-68 has a high specific surface area and a porous framework structure,which make the NMOFs fluorescent probes have higher sensitivity.We utilized NMOFs fluorescent probes to image H2S cells and in vivo.The above studies show that the metal-organic framework have good biocompatibility;with its high specific surface area and porous structure,it gives the probe higher sensitivity and selectivity.It can be used not only for molecular sensors,but also for imaging of cells and biological systems,and has a fair prospect of biological application.