Electrochemical Synthesis Method Of Biaryl Six-membered Ring Lactone Compound

Aromatic lactones are an important class of organic compounds,which exhibit a key structure in a variety of natural products,pharmaceutical agents and functional materials.In recent years,the use of C-H activation strategies for the synthesis of aromatic lactones has received much attention.However,due to the deficiencies in the developed methods,such as poor compatibility with functional groups,the substrate has low universality and the reaction conditions are relatively complicated.In the study of this paper,we developed a green and mild organic synthesis method to achieve the synthesis of aromatic lactones.Electrochemical synthesis methods have received great attention in recent years because of their green and high-efficiency characteristics.Many reports have shown that electrochemical synthesis is a powerful synthetic tool to achieve organic chemical synthesis.In this context,we have developed a method for the synthesis of aromatic lactones by electrochemistry using 2-phenylbenzoic acid as a substrate.Compared with the developed methods,this synthetic method has the advantages of mild reaction conditions,wide substrate universality and the like.In addition,the only by-product of this synthesis method is hydrogen which is easy to leave,the atomic utilization of the reaction is high,and the waste generated is small,in line with the green chemical concept.In addition,we also carried out a magnification reaction on a 100-gram scale to further verify the adaptability of the method.In the work of this paper,we also explored the reaction mechanism,using the cyclic voltammogram,electron paramagnetic resonance,and free radical capture experiments to elaborate the detailed process.