Preparation Of Multifunctional Polydopamine Nanomaterials And Application In Cancer Theranostics

For a long time,cancer has been one of the most major diseases which are difficult to cure in clinical treatment and medical research.To the treatment of cancer,the traditional methods including surgery,chemotherapies and radiotherapies,but these methods are often unable to achieve the desired therapeutic effect.Chemotherapy and radiotherapy all suffer from their severe toxic side effects to normal tissues,which cause serious pain to the patients.With the rapid development of nanomaterials,which has attracted tremendous interest in chemo-photothermal.The nanoparticles(NPs)can convert laser into heat and locally rise the temperature to kill tumor cells in the photothermal therapy,which also has the advantages of non-invasiveness,precision,low side effects and high efficiency.At the same time,the NPs can be used as the carriers to deliver the anticancer drugs and release drugs by controlled conditions to therapeutic purposes in the chemotherapy.At present,various types of nanomaterials have been explored as the chemo-photothermal agents,the polydopamine(PDA)NPs have also been considered promising in biomedical applications,because of their strong near-infrared(NIR)absorbance and photoacoustic(PA)imaging feature.However,it is still a huge challenge for us to increase the drug loading of PDA NPs and enhance their degradation features.In order to solve the problems,we designed and synthesized two kinds of multi-functional PDA NPs,which have good applications in the chemo-photothermal treatment.In this paper,we report a simple and reproducible method to obtain the multi-functional single-pore PDA-PEG NPs.The as-fabricated NPs have a high drug-loading space due to their special morphology,and the NPs also possess high photothermal conversion efficiency and pH/NIR dual-responsive controlled drug release for chemo-photothermal therapy.In addition,the biocompatible single-hole PDA-PEG NPs can be explored as new cancer theranostic agents for the PA imaging capability and biocompatibility.In next work,in order to endow the degradable ability of the NPs,we synthesized the multi-functional bowl PDA@degradable fluorescent organosilica(bowl PDA@dfOS)composite NPs.The PDA can be utilized as photothermal therapy agent,and the fluorescent organosilica shell formed by growing organosilica and modifying fluorescein isothiocyanate(FITC)onside the surface of PDA/calcium polyacrylate(PDA/PAA-Ca)NPs.And the obtained bowl PDA@dfOS NPs possess excellent drug loading and fluorescence intensity and good degradability.Meanwhile,the DOX release from the DOX-loaded bowl PDA@dfOS NPs can be controlled under pH/NIR conditions.Additionally,the rapid degradation of organosilica induced by glutathione(GSH)leads to further release the drug.Therefore,our synthesized bowl PDA@dfOS NPs are promising chemo-photothermal theranostic agents in the biomedicine field.