Study On Intramolecular Dearomatization Of Alkyne And Sulfonylation

This thesis mainly discusses the use of sodium sulfinates as a source of sulfonyl radicals and the sulfonylation dearomatization of biaryl ynones to construct spiro[5.5]trienones.The content of the paper is mainly divided into the following two chapters:1.Studies on the synthesis of spirocyclohexenedione structure by intramolecular dearomatization of alkynes and the sulfonylation reaction of sodium sulfinateThis chapter is mainly introduced from two parts.In the first part,we introduce the study of the reaction of alkyne in the intramolecular dearomatization synthesis of molecules containing spirocyclohexenedione.According to the way of the reaction,we have introduced the dearomatization reaction in recent years from three parts.In the second part,we studied the sulfonylation reactions of the formation of C-SO₂bond involved sodium sulfinates,then we classified the types of reactions and introduced corresponding reaction processes.2.Sulfonylation/Dearomatization of biaryl ynonesIn the second chapter,we mainly introduce the study of sulfonyl radical induced intramolecular dearomatization reaction of biaryl ynones with sodium sulfinates.The advantages of the reaction are that:（i）various substituted spiro[5.5]trienone compounds can be obtained in a high yield under mild conditions,（ii）the reaction time is short and the operation of the experiment is simple,（iii）Mn（OAc）₃·2H₂O is an inexpensive oxidant and commercially available.