Construction And Application Of Stimulating Responsive Polymer Grafted Gold Nanoparticle Assembly

Inorganic nanoparticle assemblies have special nano-scale structures and can be widely applied in photothermal therapy,drug controlled release,bioimaging,etc.The spatial arrangement and alignment of nanoparticles are the key factors that affect the structure and properties of the assemblies.Among all the methods,using block copolymer to stabilize nanoparticles and control the assembly of the nanoparticles by directional interactions from the molecular tethered is an efficient way to obtained desired entities.At present,there are few researches on the influence of structural parameters of ligands on the assembly behavior of polymer grafted nanoparticles.In addition,in the field of drug controlled release,how to construct nanocarriers by regulating the structure of surface ligands,and on this basis,the regulation of the disassembly behavior of nanoparticle carriers is still facing challenges.Aiming at the above problems,this thesis constructs a variety of gold nanoparticle assemblies through selective solvent method and nanoprecipitation method.The UV-responsive gold nanoparticle vesicles can be applied in photothermal therapy,drug controlled release and other fields.Details as follows:(1)We graft the amphiphilic block copolymer ligand with light sensitive group(truxillic acid)on the surface of gold nanoparticles.Then we used nanoprecipitation method to construct the vesicle structure.The anticancer drug(DOX)could be encapsulated in the same time.When the vesicles was under deep-UV light((27)260 nm),the PS chains would dissociate from the vehicles and the hydrophilic properties of a signal gold nanoparticle increased,the vesicles would disassembled accordingly and the encapsulated drug could also release from the vesicles.Moreover,the process of disassembly of the vesicles can be controlled by changing the irradiation time.(2)We graft the amphiphilic block copolymer ligand(PS-b-P4VP)on the surface of gold nanoparticles and construct different gold assemblies.We also studied the effect of the molecular parameters of the ligand and assembly condition on the assemble behavior of block copolymer-tethered nanoparticles in selective solvent.Due to the acid response of PV4P,the assemblies are expected to be applied in the fields of drug controlled release,catalysis and so on.