Preparation Of Single Chiral Gels Of Amino Acid Derivatives And Study On Chiral Recognition

At present,supramolecular chiral materials have attracted extensive attention in the field of supramolecular chemistry and molecular self-assembly.Supramolecular chiral gel materials have macroscopic chiral signals and dispersed active sites in the three-dimensional network structure with outstanding potential application value.In this paper,a series of chiral amino acid molecules were designed and synthesized.Modern analytical instruments was analyzed chiral gel material composition,structure and properties by environmental scanning electron microscope,Fourier transform infrared spectrometer,ultraviolet visible light spectrophotometer,rheometer and atomic force microscopy.The chiral drug release experiment and chiral recognition mechanism of gel materials were carried out to explore its application in the field of biological drug delivery and chiral recognition.The specific research content of this paper is as follows: 1.The L-aspartic acid derivatives(NAAPD)were designed and synthesized.A two-component NAAPD/GO gels were prepared.The NAAPD/GO gel material was characterized by scanning electron microscope,Fourier transform infrared spectrometer,X-ray powder diffractometer,atomic force microscope and rheometer to analysis gel forming mechanism and chiral property.The drug release ability and anti cercariae ability of the gel material were investigated through drug release and in vitro anti cercariae experiment.2.A series of amino acid derivative molecules were designed and synthesized with acyl chloride.A series of single-component amino acid derivative gel materials were prepared.The gel forming mechanism and chiral properties of the single-component amino acid derivative gel-materials were investigated by ultraviolet visible light photometer,fourier transform infrared spectrometer,scanning electron microscope and rheometer.3.The chiral gel materials of single components of T-L-phenylalanine derivatives and single components of T-D-phenylalanine derivatives were used to study the recognition effect with chiral naphthylamine molecules.The chiral gel materials were characterized by scanning electron microscopy,ultraviolet visible light photometer,Fourier transform infrared spectrometer,X-ray powder diffractometer and rheometer.The recognition effect of chiral naphthyl ethylamine in a single gel material was studied by SEN,NMR and drug release.