Nanomaterial Composite Hydrogel For Photothermal/photodynamic Therapy

Proteins are a class of molecules that play an important role in organisms.Protein-based peptide hydrogels have good biocompatibility,simpler linear structure,easier handling and synthesis.In addition,specific designed peptides have the ability to mimic certain properties of a protein.Due to the excellent properties of peptide hydrogels,their use in the biomedical field is of concern and worthy of study.As an emerging treatment,photothermal/photodynamic therapy has its unique advantages over traditional treatments.While improving the traditional treatment methods,it is also necessary to study new phototherapy.The purpose of this paper is to use peptide hydrogel as a carrier to encapsulate nano-materials with light responsiveness,and to study the application of hybrid hydrogels in photothermal/photodynamics.Fullerene is a known photosensitizer.Previous studies have shown that fullerene can produce singlet oxygen(ROS)in high yield even under exposure to weak visible light,and can be used as a potential photosensitizer.In this paper,the fullerene was loaded by Fmoc-FF hydrogel to form a mixed hydrogel.The rheological characterization showed that the mechanical properties of the original hydrogel were improved after the addition of fullerenes,and the fullerene and water were analyzed by spectral characterization.The intermolecular interactions between the gels as well as structural changes are further evidence of this change.In vitro and in vivo antibacterial experiments were carried out on Staphylococcus aureus.The results of the experiment showed that the mixed hydrogels had good inactivation effect on Staphylococcus aureus after light treatment,and further verified the direction of photohydrodynamic antibacterial of the mixed hydrogels.Potential application.This article also explores its potential application in photothermia therapy by using genipin and collagen hydrogels.Genipin and collagen can form a hydrogel similar to the cross-linking reaction between glutaraldehyde and collagen,because The weak mechanical properties of the collagen hydrogel itself,by changing the conditions and introducing sodium alginate to improve its mechanical properties,further verifying its internal action and changes by spectral characterization,and further verifying its photothermothermia by photothermal experiment.Application potential.In this paper,due to the good biocompatibility of the peptide,the peptide-based drug sustained-release skeleton,and the role of the gel skeleton in the dispersion and stabilization of the nanomaterial,we use it as a nanocarrier to encapsulate nanomaterials such as fullerenes.It studies the killing effect on tumors and bacteria by photodynamics and photothermal.