Chiral Mesoporous Silica Used As Stationary Phases For Gas Chromatographic Separations

Chirality is one of the basic properties of nature.Separation of chiral compounds is considerable interest.The purpose of this thesis is to synthesize chiral mesoporous silica with different chiral resource as stationary phases for the separation of racemates in gas chromatography.The main works are listed as follows:(1)Chiral mesoporous silica(CMS)was synthesized utilizing(R)-(-)-phenylglycinol as chiral source.The capillary column of CMS was prepared by the dynamic coating method.The experimental results showed that the CMS-coated capillary column not only had better separation performance for n-alkanes,n-alcohols,and aromatic hydrocarbons,but also exhibited excellent chiral recognition ability towards 18 racemates,including alkanes,olefins,alcohols,aldehydes,ketones,organic acids,epoxides and amino acid derivatives.The chiral column possessed short analysis time,high column efficiency and high temperature resistance.(2)Chiral mesoporous silica(CMS)was also synthesized by using tetradecyl-L-valine sodium as a template for the separation of racemates as chiral stationary phase.Thirteen kinds of racemates(especially amino acid derivatives),mixture of n-alkanes and aromatic hydrocarbons could be separated respectively on the column.(4)After the chiral mesoporous silica(CMS)was obtained with chiral resource of D-phenylalanine,the prepared chiral column was able to resolve eight chiral compounds,n-alkanes,n-alcohols,aromatic hydrocarbons.(5)The synthesis of chiral mesoporous silica(CMS)utilized chiral resource of L-isolecuine,and the preparation of chiral column made use of CMS.It is shown to seen that nine racemates were separated with various degrees on this column.