Design Of Small Nanoparticles Decorated With Amphiphilic Ligands

In recent years,nanotechnology has achieved rapid development and progress,bringing great changes to all our life,bringing convenience to people.For their superior specific surface area and surface structure,special morphology and aggregation characteristics compared to general materials,they exhibit unusual physicochemical properties and have good biological activity in the living environment and makes them the application prospects in drug delivery and disease treatment have been broadened.However,with the development of human society,human beings need to constantly deal with more complex modem diseases,such as tumors,which makes it urgent for us to deepen our understanding of medical molecules and cells.In order to make the lesions reach a higher drug concentration,the traditional drugs we use now may use excessive amounts of drugs,which may cause side effects tissue dysfunction.Some nanosized agents have been developed,and have proven to be better than traditional drugs.Scientists have shown great interest in this.The process by which nanomedicines are released in target organs or target cells compared to traditional drugs depends to a large extent on the pathway by which drug particles enter human tissues and cells.In general,small molecules such as traditional drug molecules enter the cell and rely on passive diffusion processes.They are relatively non-targeting,but for nanomedicine particles,they undergo special diffusion and endocytosis pathways into diseased cells,this process causes the drug to accumulate in specific tissue cells.By this,it is possible to achieve a increase in the concentration of the drug at the target site,so that people can reduce the toxic and side effects of the drug while reducing the dosage.However,there are still many unsolved problems about the application of nanotechnology in clinical treatment.For example,due to the limitations of experimental methods,people’s understanding of some of these pathways is still not comprehensive enough,and some of the functions of proteins and other substances involved in drug internalization into cell tissues are involved.It is still uncertain,and the factors that influence the entry of nanomedicine into cells are still not fully proved.These are the new types of nanomedicine that must be learned and studied.The development of computer simulation provides a convenient means for the study of the microscopic effects of biological systems.In this paper,the dispersive particle dynamics simulation method is used to study the interaction between plasma membrane,serum protein and nanoparticles.The following content was explored:1.Interaction of serum proteins with nanoparticles.The main contents include the adsorption of nanoparticles on the surface causes the accumulation of serum proteins and the formation of protein corona.Try to prevent the formation of protein corona by surface modification.2.Exploring the interaction between membranes and nanoparticles.The main contents include the size of the nanoparticles,the composition of the surface-modified ligands,and the influence of the tension of the membrane on the intermalization pathways of the nanoparticles.The nanoparticles most suitable for medical use are found through systematic research.3.Study on the self-preservation effect of ligand molecules.The main contents include studying the special configuration of ligand molecules in solvent,and the process of spontaneously reducing protein adsorption caused by structural changes.Combined with the first two work,an idea of a new structure of ligands is proposed.