Visible Light Induced Trifluoromethylation And Radical Cascade Reactions

With the continuous exploration and development of organic fluorine chemistry,fluorine-containing organic compounds have been widely studied and applied in various fields.However,the fluorine atom has high activity and is not easy to be controlled in the reaction.Therefore,chemists often adopt a method of introducing a fluorine-containing group,among which trifluoromethyl（CF₃）is one of the commonly used groups.The ideal pesticide can be obtained by design,and the thermal stability of functional materials can be significantly improved.Over the past few years,the increasingly popular radical cascade reactions have become a useful platform for accessing densely functionalized structures owing to the fact that a multiple C-C/C-X bond-formation can be organized in a highly controlled and highly functional group-compatible manner.Collective works arelisted as follows:1.A highly effective selective trifluoromethylation of acetanilide on the C2-position with CF₃SO₂Na under visible light irradiation in dimethylsulfoxide as the solvent without external photocatalyst had been developed.2.Trifluoromethylated dihydroisoquinolinones were synthesized via visible-light induced addition and cyclization reactions from N-allylbenzamides and sodium trifluoromethanesulfinate（CF₃SO₂Na）.The reaction was achieved when Ru（bpy）₃Cl₂was used as photocatalyst,tert-butyl hydroperoxide as oxidant,Water was employed as solvent,avoiding the use of organic solvents.3.A visible-light-driven haloazidation cyclization of 1,5-enynes with TMSN₃,and N-iodo（bromo,chloro）succinimide（NIS,NCS and NBS）under metal-free and oxidant-free conditions was developed.