Preparation Of Self-assembled Nanomaterials And Application In Cancer Therapy

Nanomaterials are the driving force for the progress of science and technology,which have exerted an inestimable impact on society and economies.Nanomaterials have been effective in the treatment of cancer,and self-assembled nanomaterials have many applications in photodynamic therapy for cancer.This study focuses on the synthesis of nanomaterials by self-assembly method and discusses the preparation,formation mechanism and structural properties of self-assembly nanomaterials.Then they were applied to photodynamic therapy to further analyze the important impact on cancer treatment.The main contents of this thesis are as follows:Self-assembled fluorescent nanomaterial BCNPs were prepared by the self-assembly of 2,5-bis（4-（diethylamino）benzylidene）cyclopentanone（BDBC）and curcumin（CCM）.The drug loading of BCNPs was determined BDBC（58 wt%）and CCM（42 wt%）.Transmission electron microscopy images demonstrated that BCNPs have regular spherical core-shell structure.The structure of the core-shell nanoparticles is determined by Energy dispersive X-ray spectrometer,which shows that the core of them is BDBC and the shell is CCM.The particle size of BCNPs in aqueous solution is 115.6±12.4 nm,which has high dispersibility and good stability.Comparing with their counterparts of BDBC and CCM,BCNPs exhibit higher singlet oxygen yield and better photodynamic therapy（PDT）efficacy(IC₅₀=0.72μg/mL).Moreover,BCNPs display dramatically enhanced ability for inhibiting the growth of HeLa cells,which benefits from the synergistic treatment of BDBC and CCM under the irradiation of 450/808 nm.The results of self-assembling fluorescent nanomaterials BCNPs demonstrate the potential of using simple assembly strategy to codelivery of multiple drugs in one single formulation for cancer therapy.