Study On The Preparation And Controlled Release Properties Of Quintuple Stimulus Responsive Nanoparticles Based On Pillararene

In this paper,a new nanovalve based on pseudorotaxane structure was designed,which was then modified to the surface of mesoporous silica nanospheres?MCM-41?to prepare the acid/alkaline/Mg²⁺/redox voltage/ultraviolet light quintuple stimulus responsive nanoparticles,the controlled release properties of which were then studied.This experiment was divided into the following parts.Firstly,2,2'-dithiobis[ethylamine]-N-butylaminobenzene?Cys-NAB?as guest molecule and pillar[5]arene as host molecule were synthesized.The host-guest complexation behavior between pillar[5]arene and Cys-NAB chain was researched by Isothermal Titration Calorimetry experiment?ITC?and one dimensional NMR spectroscopy of host-guest complexation.It turned out that the movement of pillar[5]arene along the Cys-NAB chain was basically in line with expectations,and it also provided a basis for the the controlled release properties of nanoparticles.Secondly,7-??2-bromoethyl??ethyl?amine?-4-hydroxymethyl coumarin?Br-DEAHMC?was synthesized.Afterwards,Br-DEAHMC and Cys-NAB were connected to the surface of MCM-41 through the 3-isocyanatopropyltriethoxysilane to obtain MCM-Cys-NAB,RhB and BTA were then loaded into the nanoparticles,followed by the capping and encapsulation with pillar[5]arene.The morphology and structure of MCM-41 and MCM-Cys-NAB were characterized by transmission electron microscopy?TEM?,X-ray diffraction?XRD?,infrared spectroscopy?FTIR?,N₂ adsorption-desorption isotherm?BET?,thermogravimetric analysis?TGA?and solid state nuclear magnetic resonance(SS ¹³C NMR).Finally,the dynamic release curves of the nanoparticles under various stimuli were measured by ultraviolet-visible spectrophotometer,and the controlled release properties of the system was studied.It's proved that the nanoparticles have quintuple stimulus response and controlled release performance,which is also in line with expectations.Hence,the system has potential application prospects in the field of drug release and anti-corrosion coating.