| ObjectivesTo explore the changes of gray matter structure and cognitive function in patients with primary obsessive-compulsive disorder,and further analyze the relationship between altered brain regions and cognitive function,for the cause of ocd mechanism and provide imaging evidence for clinical diagnosis and treatment.MethodsA total of 36 patients with obsessive-compulsive disorder were selected and 35 healthy volunteers were selected as control group.The two groups matched in gender,age and years of education.Y-BOCS and MCCB were used to evaluate subjects for obsessive-compulsive symptoms and cognitive function.The Voxel-based morphometry(VBM)method was used to perform structural magnetic resonance scanning.On the Matlab2012 a platform,magnetic resonance raw data was processed using SPM8,REST software,and the DARTEL tool.A two-sample t-test was used to compare the difference in gray matter volume between the obsessive-compulsive disorder group and the control group.The total number of voxels with reduced or increased gray matter were expressed as K values,and clusters with K>100 voxels were considered statistically significant when P<O.005.The MNI coordinates of the voxel with the largest T value in the corresponding cluster were obtained by SPM8 software.The statistically significant cluster was superimposed on the template to generate a pseudo-color map to analyze the significant gray structure changes.There will be gray matter volume differences in the temporal lobe-marginal system(left fusiform gyrus,left superior temporal gyrus,left middle temporal gyrus,left lateral hippocampus gyrus),frontal parietal lobe(left central posterior,left The clinical symptoms and cognitive function of patients with obsessive-compulsive disorder were related to Pearson correlations between the lateral central anterior cingulate gyrus and bilateral anterior cingulate gyrus.The relationship between the changes of cerebral gray matter volume and clinical symptoms and cognitive function was analyzed.Results1.General clinical data comparisonThere were no significant differences in gender(x2 = 0.23,P = 0.81),age(T =-0.45,P = 0.220)and years of education(T = 1.01,P = 0.864)between 36 OCD and 36 healthy controls.2.Comparison of Cognitive Functions2.1 Comparison of cognitive psychology test results between OCD group and healthy control groupObsessive-compulsive disorder group line test A part(47.78±15.56),symbol code(53.00± 12.24),,the third time vocabulary learning(10.17 ± 1.68),maze A(1.50 ± 0.51),maze B,(1.69 ± 0.53)maze C(1.75 ± 0.50),maze D(3.03 ± 1.72),maze E(1.69 ± 0.77),the total of vision space learning(13.25 ± 6.53),the second time visual space learning(8.89 ± 2.94),the third time visual space learning(10.42 ± 2.51),visual space learning total score(24.69 ± 6.93),continuous operation double digits(3.14 ± 0.90),STROOP 1(95.89± 7.87),STROOP 2(68.23± 17.15)results are worse than the control group(28.20 ± 7.53,66.26 ± 7.08,11.00 ± 1.26,1.86± 0.36,1.97 ± 0.17,2.00 ± 0.000,4.29 ± 0.99,3.86 ± 1.40,20.60 ± 4.68,10.69 ± 1.69,11.74 ± 0.74,29.69 ± 4.88,3.68 ± 0.44,98.11 ± 4.86,74.60 ± 11.12).The difference was statistically significant(P < 0.05).2.2 Comparison of the results between OCD and healthy control group in the seven cognitive areasObsessive-compulsive disorder group in the information processing speed capability(23.94±9.71),and the reasoning and problem solving ability(34.00 ± 8.54)were significantly worse than the control group(50.31±6.60,47.34± 10.94),the difference has statistical significance(P < 0.05).3.Comparison of brain gray matter volume between two groups3.1A region of brain with increased gray matter volume in OCD group compared to healthy control groupCompared with the healthy control group,the brain area with increasing gray matter volume were included the temporal lobe-limbic system(left trochanteric gyrus,left superior gyrus,left middle temporal gyrus,left-sided hippocampus gyrus),frontal Parietal lobe(left central posterior,left central front anterior).The difference was statistically significant(P<0.05).3.2The brain area with reduced gray matter volume in OCD group compared with healthy control groupThe OCD group had bilateral anterior cingulate gyrus relative to the healthy control group in areas of reduced brain gray matter volume.The difference was statistically significant(P<0.05).4.Correlation of brain area and cognitive function between OCD and control groupThe brain regions with differences in the obsessive-compulsive disorder group and the healthy control group were selected,and the correlations between the clinical symptoms and cognitive function of the frontal parietal lobe,temporal lobe-limbic system,bilateral anterior cingulate gyrus,and obsessive-compulsive disorder were analyzed.The results showed that the volume of frontal gray matter was negatively correlated with maze a,category fluency,and information processing speed(r=-0.430,-0.352,-0.422;P<0.05);volume of temporal gray matter in temporal lobe-limbic system and continuous operation Positive correlation was found between the two-digit,continuous operation three-digit number(r=0.348,0.349;P<0.05),negative correlation with reasoning and problem-solving ability(r=-0.331;P<0.05),and volume of gray matter in the anterior cingulate back brain area.No correlation was found in cognitive function.Conclusions1.There were abnormal brain structure in patients with primary obsessive-compulsive disorder,include temporal-marginal system(left fusiform gyrus,left superior temporal gyrus,left middle temporal gyrus,left lateral hippocampus gyrus),frontal parietal lobe(left central posterior gyrus,left side Central front back)and bilateral anterior cingulate structures.2.In the cognitive function,the speed of information processing and the decision-making ability of reasoning and problem solving are impaired.3.The greater the volume of temporal lobe-limbic system in patients with primary obsessive-compulsive disorder,the worse the reasoning and problem solving ability;the greater the volume of frontal lobe leaf gray,the worse the information processing speed capability. |
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