Evaluating The Effect Of Amplitude-integrated Electroencephalography On The Prognosis Of Brain Function In Patients After Cardiopulmonary Cerebral Resuscitation

ObjectTo explore the characteristic of early evaluation of patients with amplitudeintegrated electroencephalogram on brain function prognosis after cardiopulmonary cerebral resuscitation.Methods1.Retrospectively analyzed the clinical data of adult CPCR patients treated in the center intensive care unit(ICU)from March 2016 to March 2017 in Henan Province People’s Hospital.The length of stay,recovery time,APACHEII,aEEG and GCS within 72 h were recorded.2.The main clinical outcome was the prognosis of brain function in patients with Cardio pulmonary cerebral resuscitation after 3 months.3.The measurement data were expressed as mean ±standard deviation x ±s,t test was used,Fisher exact probability method was used for counting data.Contingency table correlation was adopt to analysis the correlation between aEEG,GCS and prognosis of brain function.Logistics regression analysis the effects of aEEG and GCS on prognosis of brain function.The receiver operating characteristic curve(ROC curve)of two evaluation indexes on the prognosis of brain function was drawn,using the area under the curve(AUC)to appraise its prognosis of brain function.according to the optimal cut-off point to predict the prognosis of brain function.Results1.A total of 31 patients with CPCR were enrolled,Males and females are 18 and 13 respectively.;age: 18-75 years old,average(41.84 + 16.96)years;5-45 days of hospitalization,average(14.84 + 10.86)days;recovery time 1-40 min,average(19.42 + 10.79)min;APACHEII score 9-36,average(19.29 + 6.42)points.2.aEEG I(normal amplitude)in 7 cases,grade II(mild to moderate abnormal amplitude)in 13 cases,III grade(severe abnormal amplitude)in 11 cases;GCS I(9-15)in 7 cases,II(4-8)in 14 cases,III(3)in 10 cases;3.19 cases survived,12 cases died,the prognosis of brain function was good(CPC 1-2 points)in 8 cases,and the prognosis of brain function was poor(CPC 3-5 points)in 23 cases.4.T test and Fisher test showed that there was no significant difference in the prognosis of brain function between different age,sex,length of stay and APACHEII score(P>0.05);There were significant differences in the prognosis of brain function between different aEEG and GCS grades(P<0.05).5.Cochran-Armitage trend test showed that the higher the grade of aEEG and GCS,the worse the prognosis of CPCR patients(P-trend<0.05),and with the increase in GCS classification,the classification of aEEG is also increasing.Both aEEG and GCS were positively correlated with the prognosis of brain function.6.Single factor logistics regression analysis showed the aEEG(OR=37,234,95%CI=3.168-437.652,P=0.004)and GCS(OR=12.333,95%CI=1.992-76.352,P=0.007)had significant influence on the early prognosis of brain function.After adjusting for aEEG and GCS,only aEEG had a significant effect on the early prognosis of brain function.(OR=26.932,95%CI:1.729~419.471).7.The ROC curve analysis showed that in the evaluation of the prognosis of CPCR patients with brain function.In aEEG group,the AUC of is 0.913,and the optimal cut-off point is 1.5,the sensitivity is 95.7%,and the specificity is 75%.In GCS group,the AUC is 0.851,and the optimal cut-off point is 1.5,the sensitivity is 91.3%,and the specificity is 62.5%.Conclusiona EEG and GCS scores have a good correlation in the evaluation of brain function prognosis in patients with cardiopulmonary resuscitation,Theaccuracy of aEEG in the early evaluation of the prognosis of patients with cardiopulmonary cerebral resuscitation is higher than the GCS score.