Advance Maternal Age Pregnancy Complications And Adverse Pregnancy Outcomes A Retrospective Analysis

Aim: The primary objective of our study is to evaluate the Obstetrics and perinatal complications and adverse outcome of AMA and non-AMA groups.Methods: A retrospective case control study on singleton pregnancy who delivered at The First Affiliated Hospital of Guangxi Medical University in the period from January 2016 to December 2016 was analyzed.The study groups included pregnant women ages of 35 years or above who underwent prenatal diagnostic analysis included in study group and pregnant women ages of less than 35 years were in control group.The data were statistically analyzed using SPSS 16.0 by applying Chi square test and ANOVA.Analysis was done to compare the maternal and fetal adverse outcomes and complications.Results: In the comparison between advanced maternal age and non advanced maternal age women,the adverse perinatal outcomes,the frequency of neonatal chromosomal abnormality was statistically significant(p<0.05).Similarly,the fetal structural abnormality was less,but highly significance was observed in comparison with non-advance maternal age women(p<0.002).Among the two group maternal,the neonatal birth weight were not statistically significant different(p>0.05).Advanced maternal age complications were highin comparison to non-advance maternal age: iron deficiency anemia(p<0.05);Gestational diabetes mellitus(p<0.05).Due to previous caesarean delivery,elective cesarean was significantly high in advanced age maternal than non-AMA(p<0.05).There was an insignificant difference in preeclampsia,premature rupture of membrane,fetal distress,macrosomia,malpresentation,PPH(p>0.05).Conclusion: Hence,from our retrospective study,we can conclude that the advanced age maternal are more susceptible to adverse perinatal outcomes and pregnancy complications than non advanced age maternal.Thus,the maternal age is responsible for certain unfavorable pregnancy outcomes which can be prevented by encouraging them to be pregnant at right age with exclusive pre-conceptual counseling,regular prenatal care;prenatal and genetic counseling with prenatal and genetic diagnostics to reduce birth defects.