Study Of The Prognosting Factors Of Brain Function In Patients With Post-resuscitation Syndrome

Objective: Our aim was to analyze the prognostic factors of brain function in patients with sudden death after spontaneous circulation,To improve the outcome of brain function in these patients to provide reference.Methods: Retrospective analysis of the hospital from January 1,2012 to August 31,2016,sudden death outside the hospital,to restore autonomic circulation(ROSC)and survival ≥ 3 days,received the first Affiliated Hospital of Guangxi Medical University 63 patients.Refer to the International Utstein model to collect patient information.Including the cause of sudden death、sudden death place、ROSC time、 acute physiology and chronic health evaluation II(APACHII)scor、Glasgow Score(GCS),serum lactate,brain natriuretic peptide(BNP)concentration,procalcitonin(PCT)concentration.According to the patient’s hospital(or hospital 28 days)brain function score(CPC),good brain function prognosis(CPC1 ~ 2)and poor brain function prognosis(CPC3 ~ 5)were divided into two groups.And then we analyzed the clinical data of two groups.Results: The study contains 63 in total patients.40 patients(63.49%)were male patients,23(36.51%)were female patients,the average age was(52.81 ±17.65)years old.In the composition ratio of the cause of sudden death,Cardiogenic disease in 30 cases(47.62%),Brain-derived disease in 10 cases(15.90%),Lung disease 4 cases(6.32%),Other special cases in 19 cases(30.16%).There were significant differences in ROSC time,GCS score and PCT concentration between the two groups(P <0.05).the areas under ther receiver operating characteristic(ROC)of GCS was0.860,sensitivity and specificity of GCS score were 93.02%,75%.Logistic multivariate regression analysis showed that GCS score(OR=0.702,P=0.005)is an independent factor affecting the prognosis of brain function.Conclusion:Sudden cardiac death is the main cause of outside the hospital sudden cardiac death in adults,GCS score at admission is the most significant indicator of the prognosis of brain function within 28 days of hospitalization,provides a reference for early prognosis.