Clinicopathological And Ultrasonographic Characteristics In Thyroid Papillary Carcinoma Associated With Hashimoto Thyroiditis

ObjectiveTo analyze the clinicopathological and ultrasonographic characteristics in thyroid papillary carcinoma associated with Hashimoto’s thyroiditis.And the factors influencing intranodular vascularity in PTC were further analyzed.Materials and Methods298 thyroid cancer patients undergoing thyroidectomy from January 2013 to February 2018 at The Affiliated Suzhou Hospital of Nanjing Medical University were collected,from which,48 PTC patients coexisting with HT were selected as the study group,and 70 PTC patients without HT were selected as the control group.The clinicopathologic features of two groups were analyzed and compared:Gender,age,tumor maximum diameter,whether it was a microcarcinoma,whether it was a multiple lesion,and whether there was lymph node metastasis.Using Philips iU Elite,GE Logiq E9 color Doppler ultrasound diagnostic instruments,the two-dimensional sonographic characteristics of two groups were analyzed:structure,echoic texture,shape,edge,presence or absence of calcification and calcification type,presence or absence of halo.The intranodular vascularity of each group of PTC was then observed by color Doppler ultrasound.Results(1)PTC patients with HT had a greater female proportion,younger age,higher proportion of microcarcinoma,smaller tumor size,more multiple lesion and lower lymph node metastasis rate,compared with those PTC without HT.However,There had no significant difference in age,tumor size,multiple lesion and lymph node metastasis rate(P>0.05).(2)The ultrasonographic characteristics of PTC,which included structure,echoic texture,shape,edge,calcification,halo sign,were no significant differences between the two groups(P>0.05).(3)Most of PTC coexisting with HT had no intranodular vascularity,while most PTC without HT had intranodular vascularity.The intranodular vascularity was not common in ≦10 mm PTC,but more common in>10 mm PTC.ConclusionsPTC coexisting with HT is more common in women,mostly microcarcinoma,with a trend for a better prognosis:smaller tumour size,lower incidence of lymph node metastasis,although these findings are not statistically significant;With typical gray-scale ultrasound characteristics of PTC;Color Doppler imaging shows no intranodular vascularity mostly.The intranodular vascularity is not only associated with the size of PTC but also with the HT existence.