The Application Of 3D-ASL In Cerebral Small Vessel Disease With Affective Disorder

Objective: The purpose of this study is to find the correlation between regional cerebral blood flow changes and cerebral small vessel disease with affective disorder,and to direct early identification and intervention.Methods: A total of 44 patients with cerebral small vessel disease were included in the study.We measured patients with Hamilton Anxiety Scale(HAMA)、Hamilton Depression Scale(HAMD)and montreal cognitive assessment Scale(Mo CA).Collect clinical characteristics and laboratory examinations.3D-ASL was performed on 34 patients.Finally,we use the GE AW Function Tool to calculate the CBF values of the regions of interest(ROI)in frontal lobe,medial temporal lobe and basal ganglia.Results: There was no statistically significant difference between the two sides and the different parts of the bilateral cerebral hemispheres in the patients without affective disorder.In patients with cerebral small vessel disease with affective disorder,the cerebral blood flow of the left frontal lobe and basal ganglia region were lower than the right side and the difference was statistically significant.However,the bilateral cerebral hemisphere,the different groups and the bilateral medial temporal lobe had no statistically significant difference.There was statistically significant difference between the group with affective disorder and the group without affective disorder.In patients both with affective disorder and cognitive impairment,the cerebral blood flow of the left frontal lobe was lower than the right side and the difference was statistically significant.However,the bilateral cerebral hemisphere,the different groups and the bilateral medial temporal lobe and basal ganglia region had no statistically significant difference.There was a statistically significant difference between the group with cognitive impairment and the group without cognitive impairment.Conclusion: Cerebral small vessel disease with affective disorder was associated with decreased cerebral blood flow in the left frontal lobe and left basal ganglia.The patients both with affective disorder and cognitive impairment was associated with decreased cerebral blood flow in the left frontal lobe.