Chemical Constituents Of Two Illicium Plants And Artemisia Carvifolia

This thesis elaborated the studies on the chemical constiuents of two Illicium plants(Illicium majus,Illicium verm)and Artemisia carvifolia.Nighty-four compounds,including eight novel ones were isolated from above species.These compound hich covered sesquiterpenoids,lignans,diterpenoids.flavanones,triterpene as well.Chapter 1 Investigation on Chemical Constituents of Illicium majusChapter 1 which focused on the purification and elucidation of the chemical and biological components from the stem barks of Illicium majus,Their structures were identified by applying modern Instrument analysis methods,45 compounds,including 5 new ones were isolated from the stem barks and fruits of majus,which covered s sesquiterpenoids,lignans,diterpenoids.flavanones as well.Illicium majus Hook et Thoms(Illiciaceae)is a toxic tree,which is mainly distributed in thesouthern part of China.1 Angustanoic acid J*2 Angustanoic acid k*3 Angustanoic acid L*5 Gustamoic acid6 Angustanoic acid E7 Majusanic acid A(7)8 15-hydroxy-8a,9a,13a,14a-diepoxyabietan-18-oic acid9 4-epi-Isopimaric acid10 4-epi-Sandaracopimaric acid11 Jiadifenoic acid N12 jiadifenoic acid I13 Jiadifenoic acid J14 3-Eudesmene-1?3-11-diol15(1?,6?)-Eudesm-4(15)-ene-1,6-diol16 Cryptomeridiol17(+)-4,5-epi-Cryptomeridiol19 7-Epi-4-eudesmene-1?,11-diol20(IR,4S,5S,10R)-Eudesma-6-en-1,11-diol21 ?-Chenopodiol22 4(5)-Eudesmene-6?,11-diol23 1(2H)-Naphthalenone,octahydro-5-hydroxy-2,5-dimethyl-8-1-methylethyl24 7?,11-Dihydroxy-cadin-10(14)-ene25 1(2H)-Naphthalenone26 3a,12-dihydroxycadina-4,10(15)-diene27(-)-aromadendranediol28 Centdarol29 1-Naphthalenemethanol,6-(benzoyloxy)-3,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl30 1,1'-di-2-propenyl-3,3,3'-dihydroxy-4,4'-dimethoxy-5,5'-biphenyl31 1,1'-di-2-propenyl-3,4,3',4'-tetramethoxy-5,5'-biphenyl32 1'-Biphenyl,2,2'-dimethoxy-5,5'-di-2-propenyl33 3,4'-Dihydroxyflavone34 3-O-?-L-Rhamnopyranosylquercetin,quercitrin35 3,3',4',5,7-Pentahydroxyflavone36 Kaempferol(KF)37 Pinoresinol38(7S,8R)-4,7,9-trihydroxy-3,5,3',5'-tetramethoxy-8-O-4'-neolignan-8'-ene39(7R,8S)-4,7,9-trihydroxy-3,5,3',5'-tetramethoxy-8-O-4'-neolignan-8'-ene40 Verimol G41 1,1'-Biphenyl]-4-carboxylic acid42 3-(4-dihydroxyphenyl)-,(1R)-1-methylhexyl ester43(4,4'-Dihydroxydiphenyl)dimethylmethane44 N-Methyl-4-hydroxyanilineChapter 2 Investigation on Chemical Constituents of Illicium verm Illicium verum Hook.F belong to genus Illicicum of family Magnoliaceae,It is mainly distributed in west and south of Guangxi province of China.This plant,popularly kown as spics,traditional Chinese medicine and raw material of perfume.We investigated on the MeOH exat of fruit and stem barks of Illicium verm.Thirty-seven compounds were isolated and identified.The key compound shikimic acid which is the pro-drug of Oseltamivir.Oseltamivir is the first-line the viral neuraminidase inhibitors.We use HSCCC(High-speed Countercurrent Chromatography)to optimizing the separation and purificationmethods.1 8-(4-Methoxybenoloyl)anethole glycol,verimol A2 7-(4-Methoxybenzoloyl)anethole glycol,verimol B3 Verimol L4 Verimol M5 Secoisolariciresinol6.Verimol H7.Verimol N8(3R,4R,3'R,4'R)-6,6'-Dimethoxy-3,4,3',4'-tetrahydro-2H,2'H-[3,3']bichromenyl-4,4'-diol9 Dibutyl terephthalate10 Verimol O11(1R,2R)-1-(4-Methoxyphenyl)propane-1,2-diol12(1 S,2R)-1-(4-Methoxyphenyl)propane-1,2-diol13 3-(4-Methoxyphenyl)-2(E)-propenoic acid14(±)-(1R,2R)-2-Hydroxy-l-(4-methoxyphenyl)propyl acetate15(±)-(1R,2R)-l-Hydroxy-l-(4-methoxyphenyl)propan-2-yl-acetate 163-(p-Methoxyphenyl)-2-propen-l-ol17(2R)-2-Hydroxy-1-(4-methoxyphenyl)-1-propanone18 1-(4-Methoxyphenyl)-1-propanol19 1-Methoxy-4-propenylbenzene20 trans-(3,5-Dimethoxyphenyl)-propene21 1S,2S)-1-(4-Methoxyphenyl)-1,2,3-propanetriol22(1R,2R)-1-(4-Methoxyphenyl)-1,2,3-propanetriol23 Naphthalenol,decahydro-2-methyl-5-methylene-8-(1-methylethyl)24 Shikimic acid'25(1'R,2'R)-Anethole Glycol26 4-(4-Methoxyphenyl)-2,2,5-trimethyl-1,3-dioxolane27 1'-Biphenyl,2,2'-dimethoxy-5,5'-di-2-propenyl28 1'-Biphenyl,2,2'-dimethoxy-5,5'-di-2-propenyl29 2,2'-Dimethylbiphenyl30 4-Methoxybenzaldehyde31 4-methoxyphenyl 4-methoxybenzoateChapter 3 Investigation on Chemical Constituents of Artemisia carvifoliaArtemisia carvifolia which focused on the isolation and elucidation of the chemical constituents from the stem barks of Artemisia carvifolia 18 compounds,including 2 new ones were insolated and elucidated It is mainly distributed in Jilin,Liaoning,Hebei,Shanxi,Shandong,Jiangsu,Anhui,Zhejiang,Jiangxi,Fujian,Henan,Hubei,Hunan,Guangdong,Guangxi,Sichuan,Guizhou,Yunnan province.The compound Artemisinin,the key ingredient of first-line antimalarial drugs,has large demand every year.Due to the big victory in the antimalarial battle,the 2015 Nobel Prize goes to the discoverer of artemisinin-based therapy for malaria1*2Artemisolide3 8R-Hydroxyarborescin4 qinghaosu5 Deoxyarteannuin6*7 7-Methoxyesculetin8 N-(N-????-L-?????)-O-???-L-????(N-(N-benzoyl-L-phenylalanyl-)-O-acty l-L-phenylalanol9.3,4-dihydroxycinnamate10 p-sitosterol11 Stigmasterol12 3,6,7,3',4'-Pentamethylquercetagetin13 3,6,7,4'-Tetra-O-methylquercetagetin14 4',5,7-Trihydroxyflavone15 3-Methoxy-2-(4-methoxyphenyl)chromone16 ThevetiaflavoneChapter 4 Progress of compounds and their bioactivity from IlliciumThis review covers the progress of compounds isolated from the genus of Illicium and their bioactivity.