Relationship Between The Cumulative Mean Arterial Pressure And All-cause Death In Kailuan Cohort

Objective To explore the relationship between the cumulative mean arterial press ure and all-cause death in Kailuan cohort.Methods A total of 56039 subjects who attended 2006-2007,2008-2009 and 2010-2011 health examination and had sufficient data were included and followed up for an average of 4.92 years.The information of death was collected trough the Kailuan Social Security Information Systerm every year.cum MAP=[(MAP1+MAP2)/2×time1-2]+ [(MAP2+MAP3)/2×time2-3],where MAP1,MAP2,MAP3 indicate MAP at examination1-3,and time1-2,time2-3 indicate participant-specific time inter val between consecutive examinations1-3 in years.All subjects were divided into f our groups by the quartile of cum MAP.The incidence of all-cause death among f our groups were compared and the correlation of cum MAP and all-cause death w as analysed by multivariate Cox proportional hazard regression.Results During a mediam follow-up of 4.92 years,1805 cases all-cause death occ urred.The all-cause mortality rate was 1.1%,2.3%,3.8%,5.6% in the first,second,thi rd and fourth quartile groups,respectively.Cox proportional hazard regression analy sis showed that adjusting for other confounding factors,including baseline systolic pressure and arterial pressure,the HR(95%CI)of all-cause mortality rate were 1.17(0.95-1.43),1.32(1.08-1.61),1.34(1.09-1.65).Conclusion 1 The all-cause mortality increases with cum MAP in Kailuan cohort.2 cum MAP is an independent risk factor for all-cause mortality in Kailuan cohort.3 cum MAP is a greater risk factor than baseline MAP for all-cause mortality in Kailuan cohort.