| Objective: Since ancient times,there is a saying that "the secret of traditional Chinese medicine lies in the dose".It has two meanings: A person who keeps a secret and keeps it secret;It’s hard to understand them,and they can’t survive.That’s the key.Prescription dosage has always lacked a unified standard and systematic theoretical system.Most of the relevant Chinese medical works in the past dynasties are related to the efficacy and processing of theory,law,prescription,medicine and medicine.The systematic discussion of drug dosages is rare,and the amount of drug is affected by many factors,making it "the secret of no transmission".The study on the dosage and related problems of the drug agents in the traditional Chinese medicine culture has formed an important research field in the inheritance and development of TCM culture.In this study,we summarized the literatures related to TCM classical prescriptions and analyzed the relationship between the dosage of prescription drugs and prescription compatibility,efficacy and safety.The volume of books is very small,and the amount of the drug is influenced by many factors,making it a "secret".Methods:This study USES the method of philology to study the classical prescriptions of traditional Chinese medicine."ShangHan lun","Jin gui yao lve","Zhou Hou fang","Qian Jin Yaofang ","Qian Jin Yifang","Tai ping Sheng Hui fang","Tai pingHui min He Ji Ju fang","ShengJi Zong lu","PuJi fang ","Yizong jin jian" ancient classics uch as the content of the relevant clinical dose in the medical,Were retrospectively analyzed,according to classical prescription doses and its related problems in mining and analysis,analysis of the relationship between dosage and herbal prescriptions classic as well as the relationship between the dose and efficacy,and safety.And by other medicine dose basis in clinical application and pharmacological experiment literature research,illustrate the compatibility of scientific,analysis of clinical dosage in series play a role in the best dose.Result:1.Dose decided to ingredients in prescriptions of position: the relationship between the dose and protect the formulas presented positive correlation,the relation between the dose,the greater the more likely they are to become your medicine,in the party official medicine.There is no corresponding between dose the formulas are in the relationship.2.The comprehensive role and trend of drug compatibility in the dose determination prescription: the dosage proportion influences the play of the inherent role of the drug flavor,and determines the comprehensive role of drug compatibility.It is not that the larger the drug dose,the better,the appropriate dose compatibility can make the prescription play the best role.3.The dose determines the efficacy of drugs: there is a positive correlation between drug dose and efficacy,namely,the higher the dose,the stronger the efficacy;There is a bidirectional regulation effect between drug dosage and efficacy,that is,as the dose increases gradually,the drug even has the opposite effect.The dosage is different and the efficacy is different.4.Safety of dose determination: for the drug in Chinese medicine,the dosage and safety of the drug are affected by the patient’s constitution,the processing of drugs,the method of cooking,and the method of taking the medicine.The compatibility of drugs between drugs can inhibit drug toxicity.5.Based on the quadratic compatibility of traditional Chinese medicine compound medicine effective parts: based on the theory of traditional Chinese medicine,to dismantle the research of classical prescription of traditional Chinese medicine,gradually found that the drug play a role of effective components,through the best compatibility dose,secondary to compatibility.It can not only improve the curative effect of the compound,but also greatly reduce the resources of traditional Chinese medicine,so as to maximize the benefit of patients.Conclusion:TCM is not the secret lies in the dose,dose the formulas is influenced by many aspects,such as compatibility,efficacy,and safety,clinical rigorous careful,when you sent the clinical doses,correctly grasp the reasonable compatibility,used properly,ensure drug safety.At the same time,we should use Chinese medicinal materials rationally,avoid waste of medicinal materials,and ensure the maximum benefit of patients. |