The Correction Between Severity Of Community-acquired Pneumonia In Adults And The T Cell Subset

Objective:Community-acquired pneumonia(CAP)is a pulmonary parenchymal inflammation obtained outside the hospital.These include the pneumonia which inflected by a pathogen that has a clear incubation period and occurs during the incubation period.In recent years,although the new antibiotics and effective vaccine was available,but due to the changes of pathogen and impaired function of host increases,the incidence of pulmonary infection and mortality was still unabated.All of these brought heavy burden to the society and national economy.Therefore,we studied the correction between severity of CAP in adults and the T cell subset,then discussed the significance of T cell subset in evaluating the severity and prognosis of CAP.Materials and Methods:Retrospective data was extracted from electronic database of the First Affiliated Hospital of China Medical University.Through the His system,we retrieved information of patients with CAP who admitted to the respiratory medicine in First Affiliated Hospital of China Medical University between January 2013 and January2017.493 enrolled patients were divided into low-risk group(191 cases)、mid-risk group(157 cases)and high-risk group(145 cases)according to the CURB-65 scoring system which proposed by the Chinese adult CAP diagnosis and treatment guidelines in the 2016.Measurement data and count data were analyzed by one-way ANOVA and Personc x~2,respectively.Correction was analyzed by unary linear regression analysis.Results:1.The changes of basic information in the three groups:the incidence of male was higher than that of female;The older the patient was,the higher the severity of the disease,the longer the hospital stayed,the higher the mortality rate(P<0.001);2.The changes of inflammation indexes and T cell subset in the three groups:With the severity of the illness increased,the WBC、NE、NE%、CRP and PCT were progressive increase and the levels of serum CD3~+、CD4~+、CD8~+T cells were progressive decline obviously(P<0.001);However,the ratio of CD4~+T cells and CD8~+T cells(CD4~+/CD8~+)showed no significant change among the three groups(P>0.05);3.The correction between the T cell subset with the CURB-65 score、CRP and PCT among the three groups:the levels of CD3~+、CD4~+and CD8~+T cells in CAP patients were negatively corrected with the CURB-65 score,and the levels of CD3~+、CD4~+、CD8~+T cells in CAP patients were negatively corrected with CRP and PCT(P<0.05).Conclusions:1.Men were more likely to suffer from CAP than women;The higher the age,the more serious the disease,the longer the hospital stayed,the higher the mortality rate;2.The more serious the CAP,the higher the inflammatory markers,the lower the T cell subset,the heavier the body’s immune function;3.The levels of CD3~+、CD4~+and CD8~+T cells in CAP patients were negatively corrected with the CURB-65 score、CRP and PCT,which further support for that the more serious the CAP,the immune function of the body was lower.So T cell subset can be used as an indicator to evaluate the severity and prognosis of CAP in adults.