To Explore The Association Between Familial Aggregation And Lung Function And COPD Assessment Test Scores In Patients With Chronic Obstructive Pulmonary Disease

Objective:Studies have shown that chronic obstructive pulmonary disease（or COPD）has clear familial aggregation.Patients with COPD often have multiple pulmonary function injuries,such as airflow limitation,diffuse function disorder and dynamic hyperinflation.COPD Assessment Test（or CAT）is a simple and effective method for evaluating and quantifying patients’quality of life,health status and symptoms.Lung function test and CAT scores are important for the evaluation and management of COPD.This study investigated whether COPD family aggregation was associated with lung function damage and CAT scores,and the correlation between lung function and CAT scores.Methods:A prospective analysis was conducted on the patients with COPD in Shengjing hospital of China Medical University during January 2016 to May 2017.The diagnostic criteria are in line with the 2017 global chronic obstructive pulmonary disease initiative.The gender,age,body mass index,smoking index and family history of the subjects were recorded.The case group was divided into a family history group and a no family history group according to the inquiry.A family history in which at least one of the first-degree and second-degree relatives of the patient has chronic bronchitis,emphysema or COPD is considered to have a family history,first-degree relatives include parents,children and siblings,and second-degree relatives include grandparents,siblings of parents and their children.CAT score test and lung function test were performed on all subjects（including pulse forced oscillation,plethysmography,pulmonary ventilation,dispersion function detection）.We analyzed the association between familial aggregation and lung function and CAT scores in the2 groups,and the correlation between lung function and CAT scores.Results:1.A total of 102 cases were included in the case group,among them,59 cases were in the family history group（accounting for 57.84%）,43 cases were in the no family history group（accounting for 42.16%）.There was no statistically significant difference between the 2 groups in gender,age,body mass index,smoking index and severity of airway limitation.2.There was no statistically significant difference in the other indexes between the 2 groups except the percentage of the estimated value of carbon monoxide diffusing capacity（or D_LCO%pred）（P=0.018）and the percentage of the estimated value of carbon monoxide diffusing capacity/alveolar volume（or D_LCO/VA%pred）（P=0.038）.3.There was no statistically significant difference in CAT scores between the family history group and no family history group.4.In COPD group and no family history group,forced expiratory volume in the first second%pred and forced expiratory volume in the first second/forced vital capacity were not related to COPD assessment test scores.There was a weak and positive correlation between FEV₁%,FEV₁/FVC and CAT scores in family history group（r=0.311 and0.336,P=0.018 and 0.005）.Conclusion:1.There was no relationship between the familial aggregation of COPD and the lung function.2.There was no relationship between the familial aggregation of COPD and CAT scores.3.The correlation between lung function and CAT scores is weak.