Research On The Relationship Between Serum Vitamin D Level And Non-alcoholic Fatty Liver Disease

Objective: The purpose of this study is to discuss the correlation between the level of serum hydroxyvitamin D [25(OH)D] and non-alcoholic fatty liver disease(NAFLD).Methods: A total of 100 NAFLD patients diagnosed by colour doppler ultrasound and 100 healthy controls who received halthy examination in Shengjing Hospital Medical Examination Centerin in the month of february and march 2017 was selected randomly into this study.Collect the general data and the data of hematologic chemistry,hepatitis virus,thyroid function,electrocardiogram of each object.Collect their fasting venous blood specimen,obtained and freezed the serum after centrifugal for subsequent detection of serum 25(OH)D level.Use Fibro Scan to test each object’s liver CAP to evaluate the degree of hepatic steatosis after screened by strict inclusion criteria and exclusion criteria.Finally 72 subjects completed the CAP test.Divided the 72 subjects into NAFLD group(CAP≥240d B/m,n=43)and healthy controls(CAP<240d B/m,n=29)according to the CAP value,and NAFLD group was further subdivided into mild NAFLD group(240d B/m≤CAP<265 d B/m,n=24)and moderate and severe NAFLD group(CAP≥265d B/m,n=19).Test serum 25(OH)D level of each subjects by Electrochemiluminescence.Compare the differences of serum 25(OH)D level between each group.Analysis the independent risk factors of NAFLD by Logistic regression analysis.Results: The level of serum 25(OH)D in group NAFLD was significantly lower than that in the healthy control group.The level of serum 25(OH)D in the moderate and severe NAFLD group was significantly lower than that in the mild NAFLD group.Serum 25(OH)D lever can be used as an independent risk factor for assessing the severity of NAFLD(OR=0.903,P=0.023,95%CI:0.827-0.986).Conclusion:The level of serum 25(OH)D is associated with the occurrence and severity of NAFLD.The decrease of serum 25(OH)D level is an independent risk factor for NAFLD.