Analysis Of Factors Influencing The Responsiveness Of Compaq In The Treatment Of Age-related Macular Degeneration

Objective: Currently,it is known that intravitreal injection of anti-vascular endothelial growth factor(VEGF)antagonist is preferred to treat wet age-related macular degeneration(wAMD).Objective to understand the factors that affect the response to intravitreal Conbercept therapy and to enhance the pertinence of it and improve its clinical application,we analyzed the clinical characteristics of patients with wAMD after Conbercept treatment,which is expected to provide the basis for further guidance of clinical treatment.Methods: A retrospective analysis of 44 patients(44 eyes)of wet age-related macular degeneration who received anti-VEGF drugs(Conbercept)treatment first time in Chongqing First People’s Hospital during Sep.2015 to Aug.2017.Comparing the characteristics of their best-corrected visual(BCVA),fundus examination,OCT before and after 6months of intravitreal Conbercept therapy and using the BCVA and fundus expression to determine whether the patients responded.Chi-square test and logistic regression model are adopted to analyze the initialcharacteristics of patients’ responsiveness.Result: 27.3% of eyes were non-responders as judged by BCVA,and31.8% were non-responders as judged by fundus findings.According to BCVA,fibrous vascular PED(OR 4.831,95% CI 1.583 to 199.411,P=0.045)was correlated with no response.According to the findings of the fundus,fibrous vascular PED(OR 7.021,95% CI 0.435 to 114.536,P=0.034)was related to non-response and occult choroidal neovascularization(P=0.012<0.0167,compared with classic choroidal neovascularization)with poor response.Conclusion: Although the most AMD responded to intravitreal Conbercept therapy,non-responders had initial clinical characteristics which were considered to be informative for managing the patients’ treatment.