Effect Of Dexmedetomidine Compound Multimodal Antiemetics On Prevention And Treatment Of PONV In Thyroidectomy Surgery

Objective: This study was designed to investigate the appropriate administration of dexmedetomidine in the treatment of PONV and to explore the clinical application of dexmedetomidine in the treatment of thyroidectomy surgery.Methods: Case selection was performed in our hospital from December 2015 to December 2017 based on medical history,clinical manifestations,and laboratory examinations.The patients diagnosed with thyroid tumors and concurrent thyroidectomy were femal patients aged between 20 and 40 years.120 patients were randomly divided into 3 groups(A,B,and C groups)with 30 patients in each group(n=30).A group was the loading dose group(1ug/kg/h)+ maintenance dose group(0.5ug/kg/h),B group was the maintenance dose group(0.5ug/kg/h),and C group was the control group.Three groups of patients received dexamethasone 10 mg before induction of anesthesia and ondansetron 4mg at the end of surgery.Patients who required postoperative pain were given a remedial analgesic drug,dobutamine.Postoperative record of patient records of general data for each group of patients;postoperative 0-2h,2-8h,8-12 h PONV occurrence,postoperative shivering,Ramsay scores and a period of time vital signs change;records of postoperative patients VAS scores and satisfaction;recording of hypotension and bradycardia during surgery.Results: A total of 120 clinical data and data were collected.The incidence of PONV at 0~2h after operation in group A and group B was lower than that in group C(p<0.05).The number of rescue antiemetic use was less than that of group C(p<0.05).Hypotension was more likely to occur in group A than in group B.Bradycardia(p<0.05).There were no significant differences in postoperative general data,postoperative chills,Ramsay scores,VAS scores,and rescue use of analgesics among the3 groups(p>0.05).Conclusion: The use of a sustained dose of dexmedetomidine(0.5ug/kg/h)in combination with dexamethasone and ondansetron for multimodal antiemetics can more effectively reduce the occurrence of PONV and can be maintained the hemodynamic stability during thyroidectomy surgery.