Analysis Of Risk Factors For Post Ischemic Stroke Epilepsy And The Impact Of Acute Treatment On The Morbidity Of It

Objective: This article is aimed to explore the risk factors for post ischemic stroke epilepsy and to further research the impact of acute treatment of cerebral infarction on the morbidity of post ischemic stroke epilepsy.Methods: In this study,patients arrived at the Department of Neurology of the First Hospital of China Medical University between September 2014 and February 2017 and those with a first-ever ischemic stroke and without a history of epilepsy before stroke were selected.We made further evuluation through telephone follow-up and confirmed the diagnosis of poststroke epilepsy on October 2017.The student t-test and the Chi-square test were used for univariate analysis,and the binary Logistic cumulative analysis was used for multivariate analysis.All the statistical methods were used to assess the risk factors for post ischemic stroke epilepsy and the acute treatment of cerebral infarction on the morbidity of post ischemic stroke epilepsy.Results: 1.A total of 1224 first-ever ischemic stroke patients were included in our article,40 of them developed poststroke epilepsy(3.3%)while 1184 of them didn’t till the deadline of the follow-up(96.7%).2.The results of the univariate analyses showed whether the lesion located in cortex,whether it is a cardiogenic cerebral embolism,whether the NIHSS score is more than 7 points and the post-stroke early-onset seizure have a statistical significance between the two groups after extracted the basic information(p<0.005).However,whether the patient had hypertension,diabetes,atrial fibrillation and other basic diseases and whether the patients have a history of smoking and drinking don’t have statistical significance between the two groups(p>0.05).The binary Logistic multivariate analysis showed that the whether the lesion involves cortex,whether it is a cardiac embolism,whether the NIHSS score is more than 7 points and the post-stroke early-onset seizures were the independent risk factors for post ischemic stroke epilepsy.3.Moreover,we analyzed the acute treatment of cerebral infarction to explore its relationship with the incidence of post ischemic stroke epilepsy and the results of univariant analyses showed only the usage of statins has a statistical significance(p<0.001),while thrombolysis,anticoagulation,antiplatelet,antihypertensive and hypoglycemic treatments don’t have statistical significance between the two groups(p>0.05).However,the result of binary Logistic multivariate analysis showed that the usage of statins has no relationship with the incidence of post ischemic stroke epilepsy.Conclusion:1.Cardiogenic cerebral embolism,NIHSS score more than 7,the lesion located in the cortex and the poststroke early-onset seizures are the independent risk factors for post ischemic stroke epilepsy;2.Whether using statins in the acute phase has no relationship with the incidence of post ischemic stroke epilepsy;3.Whether using antiplatelet,anticoagulation,thrombolysis,antihypertensive and hypoglycemic treatment in the acute phase has no relationship with the incidence of post ischemic stroke epilepsy.