The Clinical Study Of Precise Closed-loop Target Controlled Infusion Of Propofol Combined With Flurbiprofen Axetil In Elderly Patients Undergoing Painless Colonoscopy

Objective:The aim of this study was to observe the application of precise closed-loop target controlled infusion of propofol combined with flurbiprofen axetil in elderly patients undergoing painless colonoscopy to provide reference for the anesthesia of colonoscopy.Methods:Sixty patients with ASA?^?,aged 65⁸0 yr,undergoing elective painless colonoscopy were randomly divided into three groups?n=20?:Closed-loop target controlled infusion of propofol group?group P?;Fentanyl group?group N?;Flurbiprofen axetil group?group F?.Fentanyl was given with1?g/kg,while flurbiprofen axetil was given with 1 mg/kg at 5 min before closed-loop target controlled infusion of propofol.The BIS value was set to 60plus or minus 5,and the closed-loop target control was initiated.When the BIS value reached the set interval and stabilized for 5 min,the colonoscopy operation was initiated.HR,MAP,SpO₂,Bis index were recorded at the points of T₀,T₁,T₂ and T₃.The enteroscopy time,revival time and the dosage of propofol were recorded.After the operation and before discharge,a blinded observer assesse pain using Visual analogue scale?VAS score?and record the occurrence of adverse reactions such as nausea and vomiting and dizziness,investigate the patients'satisfaction before discharge.Results:There was no significant difference among the three groups in the distribution of height,weight,age,and the duration of colonoscopy?P>0.05?.There was no statistically significant difference among the three groups at the time of T₀,T₁,T₂,T₃ in the points of MAP,HR and BIS?P>0.05?.Compared with group P and N,the SpO₂ after anesthesia induction was significantly increased in group F?P<0.05?.Compared with group P,the dosage of propofol were significantly decreased in the group N and F?P<0.05?.Compared with group N,the revival time were significantly decreased in the group F?P<0.05?.Compared with group P,there was a significant difference on VAS at the time of after operation and before discharge?P<0.05?.Side-effects such as vomiting,dizziness and respiratory depression in group F were significantly decreased?P<0.05?.The patients in group N experienced more nausea after operation?P<0.05?.The satisfaction were significantly better in group F compared with group P and N?P<0.05?.Conclusion:The application of precise closed-loop target controlled infusion of propofol combined with flurbiprofen axetil in elderly patients undergoing painless colonoscopy can obviously reduce the amount of propofol,shorten the time of awakening,and lower the incidence of adverse reactions,moreover,it has proper postoperative analgesia effect and make patients more comfortable,which is a safe,effective method of painless colonoscopy anesthesia.