The Relationship Between Serum Albumin Level And Peripheral Neuropathy In Newly Diagnosed Type 2 Diabetic Patients

Objective: This study aims to understand the prevalence of peripheral neuropathy in patients with newly diagnosed Type 2 Diabetic Patients by observing the clinical data,studying the risk factors;and exploring the relationship between serum albumin level and peripheral neuropathy in newly diagnosed patients with Type 2 Diabetic Patients.Methods: This study was conducted in Endocrinology Department of Hebei Province General Hospital from September 2016 to October 2017.Eventually,there were selected 182 newly diagnosed type 2 diabetic patients.According to the diagnostic criteria,patients were divided into diabetic peripheral neuropathies group(DPN)and no diabetic peripheral neuropathies group(NDPN).Written informed consents were obtained from them,basic informations were recorded,which are age or gender and so on.Serum albumin,Uric acid and other parameters were analyzed by automatic biochemical analyzer.Serum C-peptide and Thyroid hormones were detected by electrochemical luminescence method.Glycosylated hemoglobin(HbA1c)was detected by high pressure liquid chromatography.All enrolled patients underwent neurophysiological examination.All statistical analysis were performed using SPSS 21.0 software.Results:1.The association of the baseline clinical characteristics between the DPN and NDPN groups.There were selected 182 newly diagnosed type 2 diabetic patients,which divided into two groups according to the results of electromyography.In the NDPN group were 119 patients and in the DPN group were 63 patients.Which the proportions were 65.4% and 34.6%,respectively.Indicating that the peripheral neuropathy in newly diagnosed patients prevalence is 34.6%.Thedata and biochemical indicators of the two groups were further analyzed and compared.There were no differences of sex between both groups.Compared with the NDPN group,the DPN group had higher age,HbA1 c levels than the NDPN group(P<0.05).The DPN group had lower levels of BMI,diastolic blood pressure and total triiodothyronine(P<0.05),whereas there were no significant difference in the leves of systolic blood pressure,total thyroxine(TT4)and thyroid stimulating hormone(TSH)between the both groups.2.Associations between serum albumin levels and peripheral neuropathy in DPN group and NDPN groupThis was no significant difference in the leves of serum albumin between the both groups.3.The associations of serum albumin levels with the prevalence of diabetic peripheral neuropathyWe divided all the participants into four groups across serum albumin quartiles(Q1: 21.8-40.5g/L,Q2: 40.51-43.21g/L,Q3: 43.22-45.76g/L and Q4:45.77-53.3g/L).From the lowest quartile to the highest quartile of serum albumin level,the prevalence of peripheral neuropathy were 40%,39%,33.3%,and 32.6%,respectively.Compared with subjects in first quartile,there were no significant decrease of prevalence of diabetic peripheral neuropathy was observed in the highest quartile.4.The analysis of influencing factors of diabetic peripheral neuropathyDiabetic peripheral neuropathy was treated as an independent factor.We detected the correlation of diabetic peripheral neuropathy with serum levels of albumin,age,sex,BMI,HbA1 c,and Thyroid hormones by multivariable logistic regression.The results indicated that there was a negative association between diabetic peripheral neuropathy and HbA1 c,age.Conclusion:1.In the newly diagnosed type 2 diabetic peripheral neuropathy patientes,the risk factors are age and HbA1 c.We should be attention to the older,new-onset diabetic patients with high levels of HbA1 c.2.With the patients of newly-diagnosed type 2 diabetes,which have higher incidence of diabetic peripheral neuropathy is higher in patients with decreased serum albumin,but this is no statistically significant.