CD4+CD25+Treg Cells Mediate The Immune Function In Acute Pancreatitis

Acute pancreatitis(AP)is a common clinical acute abdominal disease with high mortality.With the gradual deepening of studies on the pathogenesis of AP,the role of immune dysregulation in pathogenesis of pathogenesis has attracted more and more attention,which is mainly anifested as early immune response and late immunosuppression.The process involves complex changes in immune molecules and cells,such as cytokines,complement,lymphocytes,and white blood cells.CD4~+CD25~+Treg cells are a subset of CD4~+T cells which was found in recent years and play an immunosuppressive role by regulating the balance of pro-inflammatory factors/anti-inflammatory factors.The number of CD4~+CD25~+Treg cells in serum was positively correlated with the severity of AP.The severity and prognosis of AP can be determined by detecting the count of Treg cells in serum.Treg cells are also helpful in the immunotherapy of AP,but further clinical studies are needed.