Clinical Analysis Of 263 Hospitalized Syphilis Positive Cases And Syphilis Positive Coronary Heart Disease Case-control Study

Objective:This study systematically reviewed and analyzed the clinical data of syphilis-positive patients admitted to the Second Hospital of Hebei Medical University from 2015 to 2017 to further understand the distribution and clinical features of syphilis among inpatients.To investigate the clinical features of syphilis infected patients with coronary heart disease in order to further understand syphilis heart disease.Methods:1 Descriptive analysis of clinical data were performed in hospitalized patients whose Treponema pallidum Gelatin Agglutination Test(TPPA)were positive,Toluidine Red Unheated Serum were(+)or(-).2 Case-control study was done betwwen 32 coronary heart disease inpatients with TPPA-positive and Toluidine red(+)or(-)and at the same time hospitalized patients with non-syphilis infection.Results:1 Clinical characteristics of syphilis-positive patients in our hospital:All patients with syphilis in our hospital from 2015 to 2017 were Han nationality with onset in all age groups.The high incidence population was between 41-65 years old.The incidence of middle age group was the highest among all age groups,which was significantly higher than other age groups(P<0.05).The number of male and female patients increased year by year,Professional is given priority to with farmers.Secondly was the others including drivers,migrant workers,chefs,job unknown and retirement.Marriage is given priority to with married.Patients mainly from cities and counties in the district.Departmetnt which the patients came from covered almost all sections of the hospital.The main department was thedepartment of Cardiology,Neurology,Gastroenterology and other internal departments.Surgery department was mainly in neurosurgery department.Syphilis patients easily combined hepatitis or HIV infection,but they didn’t combine hepatitis and HIV infection samely.There was no significant difference between syphilis patients combined hepatitis or HIV and that of combined hepatitis and HIV samely,P <0.05.2 Clinical features of Syphilis infection in patients with coronary heart disease:2.1 Syphilis patients with coronary heart disease combining hypertension were significantly lower than that of control group,the difference was statistically significant(P <0.05).2.2.Compared with the control group,the case group is more prone to abnormal homocysteine,the difference was statistically significant(P <0.05).Conclusions:From 2015 to 2017,the prevalence of syphilis-infected patients in hospitalized patients in the Second Hospital of Hebei Medical University showed increasing trend year by year,the highest incidence age was middle-age and elderly.Department of Internal Medicine was higher incidence than that of surgical departments.Patients with syphilis-positive coronary artery disease had lower risk of hypertension and higher serum homocysteine level than patients with coronary heart disease alone.