| Objective: To explore the value of clinical application in the evaluation of collateral circulation combined with CTP and MP-CTA.Methods: Forty three AIS patients were enrolled in this study,which were all completed the examination of CTP and MP-CTA.Collateral circulation was graded through adopting the score of ASPECTS collateral circulation.The pseudo color map of CTP including CBV,CBF,MTT,TTP,which were obtained by quantitative analysis.Further,using "the affected side/the unaffected side" to obtain rCBV,rCBF,rMTT,rTTP.Besides,to measure the degree of vascular stenosis by NASCET standard.Results:1.Distribution:43 enrolled patients all met the criteria.However,12 patients were removed from the experimental process because of the loss or unqualified of the image data and the patients with less cooperation.Finally,31 were selected.According to the grade of collateral circulation,31 patients were divided into good collateral and poor collateral,respectively 20 and 11.2.Evaluation of collateral circulation and perfusion: Infarction core,good collateral was closely related to the rCBV,rMTT,rTTP(P < 0.05),Which high rMTT was the most powerful symbol.Ischemic penumbra,collateral circulation are closely related with rCBF(P < 0.05).3.The evaluation of collateral related factors: On the basis of single factor and multiple factors analysis,the degree of vascular stenosis and the first attack or not were the best predictor of collateral(P < 0.05).4.The consistency of MRA and MP-CTA in evaluation of vascular stenosis: studies showed that MRA and MP-CTA had a medium consistency(K = 0.697,P < 0.001).Conclusions:1.CTP combined with MP-CTA is the reliable imaging methods to evaluate collateral.2.High rMTT is the most powerful symbol of good collateral in Infarction core.3.Degree of vascular stenosis and the first attack or not were the best predictors of collateral circulation.4.MRA was moderately consistent with MP-CTA in evaluating the degree of vascular stenosis. |
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