Evaluation Of Drugs And Cognitive Behavior Intervention For Patients With Chronic Obstructive Pulmonary Disease (COPD) With Anxiety And Depression In Community

Objective:To investigate the incidence of COPD with anxiety and depression in community.To compare the differences between routine treatment and drugs with cognitive behavioral therapy for COPD patients with anxiety and depression and to provide an important clinical value for the prevention and treatment of COPD patients with anxiety and depression.Methods:Anxiety and depression(HADs scale)were evaluated in 200 patients with COPD in our hospital.To investigate the incidence of anxiety and depression in COPD patients,diagnose was completed by psychiatry department of our hospital according to Diagnostic Criteria of Mental Disorders-3(CCMD-3).Pulmonary function,chronic obstructive pulmonary disease assessment test(CAT)score,m MRC score,and quality of life scale(SF-36)scores were assessed for COPD patients with anxiety and depression.A total of104 patients suffered from anxiety and depression in 200 patients of COPD.A total of 92 cases were included in the exclusion criteria,so the patients were randomly divided into two groups: control group and experimental group,46 cases in each group.We randomly divide the COPD patents with anxiety and depression into two groups: the experimental group and the control group.The control group was given anti-inflammatory,anti-asthmatic,cough-stopping,expectorant and conventional oxygen therapy and the experimental group was given Deanxit and cognitive behavioral therapy based on the control group.To analyze the differences between the two groups for respiratory function,quality of life,anxiety,depression,hospitalization time and financial costs before and after treatment.the lung function of the patients was measured after treatment of 1 week and 2 weeks,and changes of CAT,m MRC,SF-36,self-rating anxiety scale(SAS)and depression self-rating scale(SDS)were compared between the two groups after treatment of 1 week and 2 weeks.Results:1.Among the 200 COPD patients,52.0% of them had anxiety and(or)depression.14.0% of them were only accompanied by anxiety,5.0% only with depression,and33.0% with anxiety and depression.2.By the balanced comparison of the experimental group and the control group,the difference on the general social demographic materials of the patients in the two groups is not significant(P<0.05).The data of the two groups is balanced and comparable.3.The FEV1 and FEV1 / FVC of both experimental group and control group increased after 2 weeks of treatment,but none of them was statistically significant(P > 0.05).There was no significant difference between the two groups in FEV1 and FEV1 /FVC after 2 weeks of treatment(P>0.05).4.After 2 weeks of treatment,the CAT scores of the experimental group and the control group decreased(P<0.05).The CAT score of the experimental group was lower than the control group,there was significant difference between the two groups(P<0.05).The m MRC scores of the experimental group and the control group decreased(P>0.05).The m MRC scores of the experimental group was lower than the control group,but there was no significant difference between the two groups(P>0.05).The total score of SF-36 in the control group increased(P> 0.05).The SF-36 total score of the experimental group increased(P<0.05),SF-36 score of the experimental group was higher than the control group with a significant difference between the two groups(P<0.05).5.After 2 weeks of treatment,SAS score and SDS score of the experimental group decreased with a statistical significance before and after treatment(P<0.05).There was no significant change for SAS score and SDS score in the control group.SAS score and SDS score in the experimental group were significantly lower than the control group after 2 weeks(P<0.05).6.After 2 weeks of treatment,there was no significant difference between the average length of hospital stay and the economic cost in the experimental group and the control group.Conclusions:The proportion of anxiety and depression is rather high for the COPD patients.For COPD patients with anxiety and depression,while we threat COPD,we should also apply the antidepressant,anxiolytic medication and cognitive behavior intervention.This study demonstrated the significant clinical effect for COPD patients with anxiety and depression in the treatment of Deanxit combined with cognitive behavior intervention.This not only improve symptoms of anxiety and depression,symptoms of COPD and degree of breathing difficulty,but also improved the life quality of the patients and not significantly increase the patient’s financial burden.