Observation On The Curative Effects Of Salvianolic Acid On NMOSD In Acute Phase And Its Effect To Serum GFAP Levels

Objective:To compare the differences of cerebrospinal fluid levels of GFAP in acute attack between NMOSD and MS,and to explore whether cerebrospinal fluid GFAP could distinguish NMOSD from MS at early.To analyze the effects of salvianolic acid on NMOSD by observing the ADL scores,EDSS scores,and serum GFAP levels before and after treatment in control group and treatment group.Methods:40 patients diagnosed with neurology from the First Hospital of Shanxi Medical University were collected from August 2016 to December 2017,including 20 patients with NMOSD and 20 patients with MS.The levels of GFAP in cerebrospinal fluid of NMOSD and MS were detected by ELISA.NMOSD patients were randomly divided into treatment group and control group.The control group used glucocorticoid and general neurotrophic drugs,including methylprednisolone,vitamins B1,B6,and B12.The experimental group added salvianolic acid 0.13 g,first add 5ml 0.9% sodium chloride injection for drug dissolution,then add 0.9% sodium chloride injection 250 ml intravenous drip treatment,pay attention to drip speed limit when instilling salvianolic acid(30 drops / mimute),both groups were treated for 14 days.The EDSS and ADL scores were collected before and after treatment.The serum levels of GFAP were collected before and after treatment.Results:(1)The level of GFAP in cerebrospinal fluid of NMOSD group was significantly higher than that of MS group(P<0.001);(2)There was no significant difference in the Barthel index between the treatment group and the control group(P>0.05).However,the Salvianolic acid treatment group had a significantly higher mean than the control group,with an upward trend;(3)There was no significant difference in the EDSS scores between the treatment group and the control group(P>0.05),but the mean of the treatment group decreased significantly,with a downward trend;(4)Serum GFAP levels decreased after treatment in both groups(P<0.001),the treatment group decreased more significantly(P <0.001).Conclusion:The level of GFAP in cerebrospinal fluid of NMOSD is significantly higher than that of MS in acute phase,and GFAP induced by astrocyte damage can be used to identify patients with NMOSD and MS.After 14 days of treatment with Salvianolic acid,the ADL of NMOSD patients increased,the scores of extended disability status scale decreased,the neurological function of patients improved.Serum GFAP levels can indirectly reflect the progression of NMOSD patients.