GRP78、Caspase12 In Breast Invasive Ductal Carcinoma And Its Clinical Significance

Objective: To investigate the expression of GRP78 and caspase12 in invasive ductal carcinoma and their clinical significances,to provide experimental evidences for better understanding the biological behavior of invasive ductal carcinoma breast.Methods: Immunohistochemistry was employed to detect the expression of GRP78 and caspase12 in breast invasive ductal carcinoma(n=100),and normal breast tissue(n=100).Abnornal expression of GRP78 and caspase12 and their relationship with clinicopathologic parameters in breast invasive ductal carcinoma was investageted.Results: 1.The positive expression of GRP78 in breast invasive ductal carcinoma and normal breast tissue was 76% and 18%,respectively.The positive expression of GRP78 in breast invasive ductal carcinoma was significantly higher than normal breast tissue(χ~2=67.523,P<0.01).2.The positive expression of Caspase12 in breast invasive ductal carcinoma and normal breast tissue was 74% and 12%,respectively.The positive expression of Caspase12 in breast invasive ductal carcinoma was significantly higher than normal breast tissue(χ~2=78.417,P<0.01).3.There was significantly elevated expression of GRP78 in patients with breast cancer in the late pathological grade,HER2 positive and non-triple receptor negative breast cancer(NTNBC)(P<0.05).The expression of GRP78 was not significantly related with the ages of patients,tumor size,WHO grade,lymthaden trasition and molecular clasification of estrogen receptor(ER),progesterone receptor(PR)and Ki67 antigen(P>0.05).4.There was significantly negative relationship between the expression of Caspase12 and the size of tumor(P<0.05).The expression of Caspase12 was not significantly related with the ages of patients,tumor size,WHO grade,lymthaden trasition and molecular clasification of estrogen receptor(ER),progesterone receptor(PR)and Ki67 antigen(P>0.05).5.There was negative relationship of the expression between GRP78 and Caspase12(r=-0.201,P<0.05)in breast invasive ductal carcinoma.Conclusion:1.GRP78 may be associated with the occurrence of breast cancer,proliferation,and invasion.2.Breast cancer Caspase12 mediated endoplasmic reticulum stress exist in the apoptotic pathway,may be involved in breast cancer cell proliferation/apoptosis.3.GRP78 expressed in three negative breast cancer is lower,but to understand the biological characteristics of three negative breast cancer provides a new direction.