Design,Synthesis And Biological Activities Of Novel Neuroprotective Agents For Acute Stroke

Acute ischemic stroke is one of the major causes of death.Many pharmacological treatments by means of so-called neuroprotective drugs such as glutamate receptor antagonists and Ca and/or Na channel blockers have been tried;however,they have not been successful in improving clinical outcome in patients.In order to explore new neuroprotective compounds,37 novel cinnamide derivatives have been designed and synthesized by using computer-aided drug design and their structures were characterized by 1H NMR,13C NMR and HRMS.Besides,we have do something with codurgs by combinating Edaravone and selective antagonist of NR2B subunit in a simple compound.9 novel target compound has been synthesized.The preliminary pharmacological screening of all the compounds showed that compound WY-1,WY-26 and WY-E2 exhibit potent neuroprotective effects.Further bioassay and structural optimizing of these derivatives as neuroprotective agents are in progress.