The Relationship Between The Prevalence And Incidence Of Hyperuricemia And Metabolic Syndrome In Jinchang Cohort

Objective To understand the prevalence and incidence of metabolic syndrome(MS)and hyperuricemia in Jinchang Cohort,and to analyze the correlation between blood uric acid level and MS and its components,in order to improve the prevention and control of MS.Methods Jinchang Cohort baseline consisted of 43,409 participants,and the follow-up consisted of 27,343 participants.Baseline epidemiological data were obtained via face-to-face interviews,and biochemical indicator data were obtained via blood tests from June 2011 to December 2013.Follow-up data were collected in the same way from January 2014 to August 2015.From the baseline data,we calculated the prevalence of hyperuricemia and MS,and analyzed the correlation between uric acid level and MS and its components.From the baseline and follow-up data,we calculated the incidence of hyperuricemia and MS,compared the incidence of MS and its components between difference uric acid levels,and compared the incidence of hyperuricemia between the MS group and the normal metabolic group.Results 1.The prevalence of hyperuricemia was 14.8%.It was higher among males than females(19.3% vs 7.6%,respectively).The prevalence of MS was higher in the hyperuricemia group than control group(30.1% vs 13.2%,respectively).The incidence of hyperuricemia was 5.7%.It was higher among males than females(6.3% vs 4.8%,respectively).The incidence of MS was higher in the hyperuricemia group than control group(15.8% vs 6.9%,respectively).The incidence of hypertension,overweight or obese,hyperglycemia,and dyslipidemia were significantly higher in the hyperuricemia group than control group.2.The prevalence of MS in Jinchang Cohort was 15.7%.It was higher among males than females(18.6% vs 11.1%,respectiely).The prevalence of hyperuricemia was higher in the MS group than control group(28.2% and 12.2%,respectively).The incidence of MS was 8.0%.It was higher among males than females(9.8% vs 5.2%,respectively).The incidence of hyperuricemia was higher in the MS group than control group(13.3% vs 5.1%,respectively).3.The prevalence of dyslipidemia was 45.5%.It was higher in the hyperuricemia group than control group(67.5% vs 41.7%,respectively).The incidence of dyslipidemia was 17.2%.It was higher in the hyperuricemia group than control group(28.6% vs 16.1%,respectively).The incidence of hypertension,overweight or obesity,hyperglycemia,and hyperuricemia was significantly higher in the dyslipidemia group than control group.4.The prevalence and incidence of hyperuricemia increased with the number of MS components in both sexes.5.The prevalence and incidence of MS increased with uric acid levels in both sexes.6.The incidence of hyperuricemia has a significantly positive correlation with blood pressure stages,body mass index,fasting blood glucose level,triglyceride level,and high-density lipoprotein cholesterol were significantly negative correlation.Conclusions 1.Middle-aged men and menopausal women are high-risk groups,who had higher incidences of MS and hyperuricemia,and should be targets for prevention and control.2.Hyperuricemia is an important factor in the occurrence and development of MS,and MS can increase the morbidity of hyperuricemia.3.Hyperuricemia has a close relationship with MS and its components,and interacts as both a cause and effect.Thus,hyperuricemia should be incorporated into the MS diagnostic criteria.