| Objective:The research was about to find out whether there are relationships among the clinical symptoms of TCM;levels of CA125,sex hormones,EFI,and r-AFS,To retrospective study on pregnancy of whom underwent conservative surgery and analysis of pregnancy-related factors.To probe methods that improve fertility chance after surgery.Methods:The 93 samples of the infertility which related endometriosis collected were screened strictly according to the inclusion and exclusion criteria.Finally,we collected60 samples in the first affiliated hospital of Anhui University of TCM from October,2015 to May,2017.To collect clinical symptoms of the qi and Blood Stasis Type;the endometriosis fertility Index(EFI);evised American Fertility Society;the levels of FSH,LH,E2 in the follicular phase;the levels of CA125 before the surgery.There are 18 months to follow-up the pregnancy rate after the surgery,until November2017.According to postoperative pregnancy,24 cases who pregnant are named pregnancy group,and 36 cases which group is unpregnant at the end of follow-up.independent sample t-test,chi-square test is used in univariate analysis;we analyse related factors of qi and blood stasis syndrome associated infertility influencing pregnancies after surgery by the analysis of binary classification Logistic regression.Results:1.In menses,58patients(96.7%)are in the line of poor,of which 13 patients don,t have blood clots,38 patients have blood clots,7 patients had blood clots which the pain can be relief.There were 52 cases(86.7%)of which 41 cases have a little breast pain,10 cases have serious breast pain,even can not touched,is 1 case.43 cases(71.7%)get premenstrual pain.37 cases get abdominal pain(61.7%);33 cases(55%)get premenstrualirritability;20cases(33.3%)of those with anal pendant dilation.17 cases(28.3%)be pain during the consummation.2.In the study of 60 patients,24 cases successful pregnancy(40%),failure to a total of36 cases of pregnancy during the follow-up period,60%.there are 12 cases which get pregnant in half a year,accounting for 50% of the total cases pregnancy,there are 8cases(33.3%)during 7 to 12 months,4 cases(16.7%)during 13 to 18 months of postoperative.3.In this study,there were 15 primary infertility cases and 9 cases of secondary infertility in the pregnancy group.There were 21 cases of primary infertility and 15 cases of secondary infertility in the team of no pregnancy.Two groups of primary infertility accounted for 62.5% and 58.3%,respectively two groups of infertility type primary infertility accounted for the main.Mainly concentrated in 26 to 30 years old,number of 44 cases,accounting for 73.3%.The average age of the pregnancy group was27.33 plus or minus 2.239 years old,The average age of the unpregnant group was28.78 plus or minus 2.929 years old,and There were statistically significant differences between the two groups(P<0.05).4.The infertile time between the two groups was 12 to 18 months,with 18 cases(30%)and 16 cases(26.7%).The duration of infertility in the pregnancy group was up to 36 months,and the longest in the unpregnant group was 72 months.and There were statistically significant differences between the two groups(P<0.05).5.The maximum numerical of FSH,LH and E2 in pregnancy group was 9.64mIU/mL,10.85mIU/mL and 305.5pmol/L respectively.the minimum is 3.39mIU/mL,.84mIU/mL,69.73pmol/L.The highest value of the unpregnant group was 9.84mIU/mL,7.75mIU/mL,890.4pmol/L;The minimum value is 2.84mIU/mL,1.67mIU/mL,and 3.31pmol/L.There was no statistically significant difference between FSH,LH and E2(P>0.05).6.Two groups of qi and blood stasis type rating: there were 6 cases in 1-5points,34 cases in 6-10 points,14 cases in 11-15 points,6 cases in 6-20 points,the highest score is20 points.The differences between the two groups were statistically significant(P<0.05).7.The maximum serum CA125 in pregnancy was 74.0u/ml,with a minimum value of10.8u/ml.The maximum value of serum CA125 in the unpregnant group was 274.4u/ml,with a minimum value of 10.2u/ml.and there were statistically significant differences between the two groups(P<0.05).8.There are 53 cases,accounted for 88.3%,in the stage of r-AFS mainly concentrated in the period fromⅡto Ⅲ,of the two groups,7 cases in the stage 0fⅠand Ⅳ,the number is small and there were statistically significant differences between the two groups(P<0.05).9.The two groups have a maximum of 10 points.There were 20 cases in the pregnancy group,which accounted for 83.3% of the total pregnancies.There were 33 cases in the ungestation group,accounting for 91.7% of the total pregnancies.There was no statistically significant difference between the two groups(P>0.05).10.By the statistical analysis,it was found that the difference between ages,the time of infertility,scores of the syndrome,the level of CA125,and staging of r-AFS was statistically significant(P<0.05).Finally,the analysis of the second classification Logistic regression get performed,and the time of infertility,scores of the syndrome and staging of r-AFS have effects on postoperative pregnancy.Conclusion:This study showed that there was no statistical difference between the the level of FSH,LH,E2,EFI in patients with the infertile.The pregnancy rate was negatively correlated with the time of infertility,scores of the syndrome and staging of r-AFS,which get more severe,the pregnancy rate was lower. |
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