Clinical Efficacy And Safety Evaluation Of Winter Disease Cured In Summer By Acupoint Application For Preventing Bronchial Asthma Attack

Objective1.Through the changes of the Asthma Control Test(ACT)scale score and the pulmonary function test value before and after treatment,the clinical curative effect of winter disease cured in summer by acupoint application therapy for preventing bronchial asthma attack was discussed.2.Carry out the adverse reaction evaluation and adverse event follow-up on acupoint application,and scientifically evaluate the safety of winter disease cured in summer by acupoint application therapy.Method The 45 patients with chronic duration or clinical remission were randomly divided into experimental group and control group by central random method.The first year was the baseline period,and all patients received the 2nd-patch(low dose)medication during dog days for acupoint application.The second year for the trial period,the experimental group using the 1th-number of application drugs(conventional drug dosage)to apply,control groups using the 2nd-number of application drugs(conventional drug dosage of 1/15)to apply.Comparative analysis after the end of the two-year observation cycle: 1.By comparison with the baseline period,the change in the score of the ACT scale to the second application year,also the changes in the second year and the third year of FEV1%,PEF,FEV1/FVC detection value before the application compared to the first year of paste before,to evaluate the therapeutic effect of winter disease cured in summer by acupoint application therapy for preventing bronchial asthma attack.2.Through evaluation of acupoint application related adverse reactions after eachapplication and the discovery of adverse events at each visit,The safety evaluation of acupoint application was carried out.Results1.ACT Score Pasted for the second year,The ACT score of the experimental group was significantly higher than the baseline period(P<0.01),there was no statistically difference between the control group ACT score and baseline period(P>0.05),and the ACT score of the experimental group was better than that of the control group(P<0.05).It is indicated that this therapy can improve the ACT score of patients with asthma.2.Clinical Efficacy Pasted for the second year,the total effective rate of the experimental group was 76.2%,the total effective rate of the control group was 50.0%,by statistical analysis,there was no statistically significant difference in total efficiency between the two groups(P>0.05).The results showed that two groups had certain clinical effects,but the total effective rate of the experimental group was higher than that of the control group.3.pulmonary function Index The test value of PEF before application in the third year of the experimental group was higher than that before the first year and the second year of application,there are statistical differences(all P<0.05),but compared with the first year and the second year,there was no statistical difference in PEF detection value before the application(all P>0.05).It is indicated that this therapy can significantly improve the pulmonary function index PEF in asthmatic patients.There was no statistically significant difference between the FEV1% test values before application in the third year of the test group and the control group compared with the first year and the second year(all P>0.05).It is indicated that this therapy has no obvious improvement effect on pulmonary function index FEV1% in asthmatic patients.The test value of FEV1/FVC before application in the second year of the control group was not statistically different from that before the first year and the second year of application(P>0.05),but the test value of FEV1/FVC before application in the second year of the experimental group was lower than that before the first year of application,there is a statistical difference(P<0.05);the FEV1/FVC detection value before the application in the third year of the test group showed no statistical difference compared with the first year and the second year(all P>0.05),but in the third year of the control group,the detection value of FEV1/FVC before application was lower than that in the first year,there is a statistical difference(P<0.05).It is indicated that this therapy has no obvious improvement on pulmonary function index FEV1/FVC in asthmatic patients.4.Safety evaluation The safety assessment of acupoint application was classified,the experimental group 1 level 2 people,2 level 15 people,3 level 4 people,4 level 0 people;the control group 1 level 13 people,2 level 7 people,3 level 0 people,4level 0 people.Comparing the safety assessment grades of the two groups,there is a statistical difference(P<0.05),It shows that the safety of the control group was better than the test experimental group,but there were no patients in the two groups who had discontinued the study because of adverse reactions or abnormal safety indicators,no adverse events occurred during the study period.Conclusion1.Winter disease cured in summer by acupoint application therapy can significantly improve the symptoms of bronchial asthma such as wheezing,shortness of breath,chest tightness,cough,dyspnea,nighttime awakening,and limited activity,reduce the dosage of first aid drugs,improve the patient’s quality of life.2.Winter disease cured in summer by acupoint application therapy can improve the maximum expiratory flow in patients with bronchial asthma,however,there was no significant improvement in the forced expiratory volume in one second as a percentage of predicted value and one second forced expiratory volume occupancy vital capacity percentage.It is suggested that this therapy can reduce the resistance to large airway in asthmatic patients to a certain extent,improve ventilatory function,improve airway smoothness and stability,but it can not fundamentally reverse the airway obstruction and respiratory disorder.3.Winter disease cured in summer by acupoint application therapy and its pharmaceutic preparation are safe and reliable,the incidence of adverse reactions and adverse events is low,patient compliance is high,and the curative effect is exact,it is worthy of further deepening and promotion in clinic.