Clinical Observation On COPD In Acute Exacerbation Period With Phlegm Retention In The Lung Syndrome And Its Effect On Peripheral Blood SAA、CCL-18 And Tgf-β1 With Siziwenfeitang And External Diaphragm Pacemaker

Objective:To observe the Siziwenfeitang combined with External diaphragm pacemaker for the clinical observation of acute exacerbation of chronic obstructive pulmonary disease with phlegm retention in the lung syndrome and the effects of peripheral blood SAA,CCL-18 and TGF-β1,to further verify the advantages of traditional Chinese medicine combined with pulmonary rehabilitation on the role of chronic obstructive pulmonary diseaseMethods:A randomized controlled method was used to study 90 patients with COPD and the TCM syndromes are phlegm-enriched lung types.It were randomly divided into comprehensive group,Chinese medicine group and control group,30 cases in each group.Thecontrolgroupwasgivensymptomatictreatmentsuchas anti-infection,antispasmodic and antiasthmatic,and phlegm.The traditional Chinese medicine group added four Siziwenfeitang on the basis of conventional treatment,comprehensive group in the basic treatment of conventional treatment plus the Siziwenfeitang combined with External diaphragm pacemaker.Treatment for ten days.To observe the TCM syndrome integral of three groups of patients after treatment.The effects of TCM syndrome integration,blood gas analysis,6 minute walking distance,peripheral blood SAA,CCL-18 and TGF-β1 were observed in three groups of patients.Results:1.There was no significant difference in gender,age,course of disease and severity of disease in the three groups,which was comparable;2.There was no significant difference in safety indicators between the three groups before and after treatment（P<0.05）;3.Comparison of clinical efficacy:after treatment,the total effective rate was 96.7%,the Chinese medicine group was 90%,the control group was 80%,and the total effective rate of the three groups was significantly different（P<0.05）.Comparison of TCM syndrome points:After the treatment,the scores of syndromes in the three groups of patients improved compared with those before treatment（P<0.05）.Comparison between groups,There was no significant difference in the three groups of poor appetite,bloating,and sticky mouth（P>0.05）.The cough,asthma,and shortness of breath in the comprehensive group and the traditional Chinese medicine group were better than those in the control group（P<0.05）.However,there was no significant difference between the comprehensive group and the control group（P>0.05）4.Comparison of SAA、CCL-18 and TGF-β1:Three groups of patients after treatmentTGF-β1、CCL-18 lower before the treatment（P<0.05）,between group contrast,maintaining and Chinese medicine group were lower than that of control group in TGF-β1、CCL-18（P<0.05）,while maintaining there was no statistically significant difference compared with the traditional Chinese medicine group（P>0.05）,the three groups after treatment in patients with SAA reduce before the treatment（P<0.05）contrast group,maintaining lower than that of traditional Chinese medicine group and the control group（P<0.05）,while Chinese medicine group is better than that of control group（P<0.05）,there was no significant difference（P>0.05）;5.Comparison of Blood gas analysis,After treatment,both PaO₂ and SaO₂ were increased before treatment（P<0.05）.In the group,the increase of the comprehensive group was significantly better than that of the traditional Chinese medicine group and the control group（P<0.05）.There was no statistically significant difference between the two groups.After treatment,PaCO₂ decreased before treatment.In the group,the reduction of the group was the most obvious,compared with the traditional Chinese medicine group and the control group（P<0.05）.There was no significant difference between the Chinese medicine group and the control group6.Comparison of 6MWD:After treatment,6MWD was increased in all three groups before treatment,with statistical significance（P<0.05）.Compared between groups,6MWD was better than the control group after treatment.The difference was statistically significant（P<0.05）.There was no significant difference between the comprehensive group and the traditional Chinese medicine group.Conclusion:1.In this study,the patients’heart rate,respiration,blood pressure,liver and kidney function and other safety indicators had no significant influence,indicating that the study was safe and reliable.2.The Siziwenfeitang combined with External diaphragm pacemaker can effectively improve lung soup copd patients with acute aggravating period of cough phlegm asthma symptoms,and help the excretion of sputum,more can effectively help patients improve artery PaO_2,SaO₂,PaCO₂ indicators,obvious advantages;3.The Siziwenfeitang combined with External diaphragm pacemaker can effectively reduce the level of peripheral blood SAA,CCL-18 and TGF-β1 in patients with chronic obstructive pulmonary disease,and improve the airway inflammation in patients.4.The Siziwenfeitang combined with External diaphragm pacemaker can improve the patient’s exercise tolerance,improve the total treatment efficiency,and have a good therapeutic effect on AECOPD patients.