Correlation Analysis Of Clinical Festures And Therapy In 113 Patients With Multiple Myeloma From One Single Centre

Objective To analyze the immunophenotype of multiple myeloma(including CD38,CD138,CD56,CD117,CD19,CD20),molecular genetics(including 1q21 amplification,RB1/D13S319 deletion,p53 deletion,IGH rearrangement)were associated with clinical manifestations,risk stratification and correlation.To explore the correlation between immunophenotype,molecular genetics and prognostic judgement,and the effect of treatment methods on the therapeutic response and clinical prognosis,and to explore the relevant factors that may influence the prognosis of multiple myeloma.For MM prognosis evaluation,clinical diagnosis and treatment decision to provide the basis.Results 1.The positive expression rate of CD117 was significantly correlated with sex and LDH level in patients with MM(P=0.049,0.036):The positive expression rate of CD56 was correlated with serum P2MG(P=0.042);The positive expression rate of CD20,CD 19,CD38 and CD 138 was not related to sex,age and clinical manifestations such as CRP,LDH,albumin,serum p2MG(P>0.05).The immunophenotype in most of the patients was changed too.The rates of CD38,CD138,CD56,CD117,CD19 and CD20 change were 5.3%,63.2%,57.9%,52.6%,15.8%,31.6%,respectively.2.There was a significant correlation between IGH rearrangement and albumin level(P=0.027).There was no correlation between the deletion of RB1/D13S319,1q21 amplification,p53 deletion and clinical features of MM patients(P>0.05).3.There was no significant correlation between cellular immunophenotype and molecular genetic abnormality(P>0.05).4.Therapeutic response:The reaction rate of the new drug group was better than the traditional group,P=0.022,and the reaction rate of the new drug group was 84.4%and 64%,respectively.The response rate of the treatment in the traditional group was significantly correlated with the 1q21 amplification(P=0.028),and the ORR in the new drug treatment group was significantly correlated with the positive expression rate of CD56 and the level of serum ?2MG,P=0.02,0.019,respectively.Therapeutic prognosis:1)The positive expression rate of CD117 was significantly correlated with risk stratification(P=0.031),and the values of OS and EFS in the patients with positive CD117 were significantly longer than those in the patients with negative CD117(P<0.05).2)OS and EFS in CD56 positive patients were longer than those in CD56 negative patients(P<0.05).3)There was a significant correlation between lq21 and risk stratification,P=0.037.4)The levels of OS and EFS in high risk group were significantly lower than those in lower risk group(P<0.05).5)The EFS and OS of the transplantation group were better than that of the non-transplantation group,but the difference was not statistically significant(P>0.05).Conclusion 1.The positive rate of first diagnosis of CD117 in female patients is higher than that of male patients;the positive rate of CD117 in patients with high lactate dehydrogenase is higher.2.The positive rate of CD56 is negatively correlated with the level of serum P2MG.3.The rate of IGH rearrangement in patients with hypoproteinemia is higher.4.In the course of treatment,the immunophenotype of the patients is significantly different.5.The prognosis of CD117 positive patients is better than that of CD117 negative patients.The survival rate of CD56 positive patients ia higher and the prognosis was better.The detection rate of 1q21 is related with poor prognosis.The response rate of new drug therapy is better than that of traditional chemotherapy,and sequential autologous transplantation may obtain better prognosis.