Study Of Functional Connectivity Density Based On Brain Image Data

According to the survey,since entering into 21st Century,the number of patients of various types of mental disorders in China has exceeded 100 million.Among them,most of patients with mental disorders are 20-39 year old young people,and most people have not received professional treatment of mental illness,which has brought great mental disease burden to the country.In order to solve this problem,it is time to find effective treatment methods for all kinds of mental diseases.Schizophrenia is a common disease of the mental’ disease.It is hereditary,and the incidence of the disease is very high in the first-degree relatives,especially in the their siblings.Based on functional connectivity density(FCD)and seed point correlation analysis method,two different ways to analyze and explore the deep pathological mechanism of schizophrenia patients are discussed in this paper.In this paper,we first used the analysis of functional neuroimages(AFNI)based on the generalized linear model(General Liner Model,GLM)to make a preprocessing and general statistical analysis of 28 schizophrenic patients and 28 matched siblings.Next,we apply a data driven method-functional connectivity density,which is used to quantitatively analyze the functional connectivity density of each voxel in the whole brain.The larger the density,the more voxels connected with the voxel,and vice versa.The distribution of the functional connection hub area can be quickly identified by this method.After the analysis of the FCD data,the results showed that the functional connection hub area of schizophrenic patients is mainly distributed in the following regions:occipital lobe,limbic lobe,posterior cingulate,middle occipital gyrus,angular gyrus,lingual gyrus.The function connection hub area of sibling mainly is distributed in the following regions:occipital Iobe,precuneus,cerebellum posterior lobe,limbic lobe,lingual gyrus,posterior cingulate gyrus,postcentral gyrus,superior frontal gyrus,middle frontal gyrus.In addition,we also found that the core FCD region of patients with schizophrenia is distributed in the right precuneus,left precuneus.Its sibling core FCD region not only have the above two areas of the brain,but also increased the right lingual gyrus,which may reveal the patients with schizophrenia core FCD regional anomaly.On the basis of FCD analysis of patients and their siblings,we adopt the seed correlation analysis method to analyze the whole brain function connection of schizophrenics and their siblings.The most important thing in the analysis of seed points is the selection of seed points.The previous selection of seed points is generally based on prior knowledge,and we are selected with the results of FCD.In this study,three core FCD regions of the schizophrenic patients and their siblings,including the right precuneus,the left precuneus and the right lingual gyrus,were selected as the region of interest(ROI),which further analyzed the resting state fMRIbrain connection for the patients and their siblings.Analysis based on voxel-wise seed points shows,compared to its sibling,patients with schizophrenia were significantly reduced in the connection strength of three seed area.Its abnormal brain regions mainly are distributed in the following regions:superior frontal gyrus,middle frontal gyrus,inferior frontal gyrus,superior temporal gyrus,middle temporal gyrus,precentral gyrus,occipital lobe and limbic lobe.In this paper,we use FCD and seed point correlation analysis to explore the environment relationship of schizophrenia from two different forms,which provides a reference for clinical diagnosis and treatment of schizophrenia.