Application Of Automated Breast Volume Scanner In Breast Diseases

Objective:To investigate the diagnostic value of automated breast volume scanner in benign and malignant breast lesions of different types of ultrasound.Methods:Data from 196 breast lesions confirmed pathologically were analyzed.Every patient accepted examination by ABVS before operation.According to the proportion of the breasts,they were divided into four types:glandular type,glandular fibro type Ⅰ,glandular fibro type Ⅱ and fatty type.Based on pathological results,the ROC curve was drawn to analyze the diagnostic value of ABVS for four types of breast lesions,and the diagnostic performance of ABVS for lesions of four types was compared by Z-test.Results:Area under ROC curve of ABVS in differentiating benign and malignant lesions of four ultrasound types were 0.950(glandular type),0.983(glandular fibro type Ⅰ),0.907(glandular fibro type Ⅱ)and 0.941(fatty type)respectively.Comparing the area under the curve,there was no significant difference between the diagnostic performance of ABVS for lesions of four types(P>0.05)Conclusions:In the differentiation of benign and malignant lesions of the breast,ABVS has a high diagnostic value,whatever the breast type of ultrasound is.PART Ⅱ Diagnostic performance of ultrasound elastography combined with the automated breast volume scanner in differentiation of benign and malignant breast imaging reporting and data system 4 breast lesionsObjective:To investigate the diagnostic performance of the combination of US elastography(UE)and automated breast volume scanner(ABVS)in differentiation of benign and malignant breast imaging reporting and data system(BI-RADS)4 breast lesions.Methods:Data from 137 patients with breast diseases(147 tumors)confirmed pathologically(by surgery or biopsy)were analyzed.Every patient was examined by ABVS and UE.All tumors were diagnosed as BI-RADS 4 by ABVS.With final pathology results as the gold standard,the Receiver Operating Characteristic(ROC)curve was drawn to analyze the diagnostic value of UE and the combination of UE and ABVS in differentiating benign and malignant BI-RADS 4 breast lesions.Results:Pathological findings were as follows:of the 137 patients with 147 breast lesions,54 were benign and 93 were malignant.In differentiating benign and malignant BI-RADS 4 breast lesions,the diagnostic sensitivity,specificity and accuracy of UE were 94.6%,57.4%and 81.0%,and the diagnostic sensitivity,specificity and accuracy of the combination of UE and ABVS were 98.9%,57.4%and 83.7%.The ROC curve showed that the area under the curve of the combination of UE and ABVS was 0.965,which was greater than 0.858(the area under the curve of UE).Therefore,the performance of UE combined with ABVS in differentiating benign and malignant BI-RADS 4 breast lesions is better than UE alone.Conclusions:UE has certain value in differentiating benign and malignant BI-RADS 4 breast lesions,especially when combining with ABVS,it could improve its diagnostic accuracy.UE combined with ABVS can improve the detection rate of malignant lesions in BI-RADS 4 breast lesions and reduce the rate of preoperative biopsy,which has a good application prospect.PART Ⅲ Analysis of coronal plane imaging features of automated breast volume scanner in different molecular subtypes of breast cancerObjective:To investigate the correlation between the coronal imaging features of automated breast volume scanner(ABVS)and different molecular subtypes of breast cancer.Methods:Data from 153 breast cancer patients(157 tumors)confirmed pathologically were analyzed.Each tumor was examined by ABVS for coronal imaging features and by immunohistochemical analysis to obtain the molecular subtype(Luminal A,Luminal B,Her-2 and Triple-Negative subtype).The clinicopathological characteristics and imaging features of different molecular subtypes were compared.Results:According to the immunohistochemical results,the lesions were classified into Luminal A(32),Luminal B(85),Her-2(22)and Triple-Negative(18).We found significant difference in boundary,microcalcifications and indirect signs on the coronal plane between the four subtypes(P<0.05).The Luminal B and Her-2 subtypes were more commonly seen with microcalcifications(69.4%and 77.3%,respectively).Retraction phenomenon occurred more frequently in Luminal A subtype(43.7%)than in others.Clear boundary was more often found in Triple-Negative subtype(27.8%).No statistically significant difference was found in clinicopathological characteristics and margin shape among the four subtypes(all P>0.05).Conclusions:The coronal imaging features have a certain correlation with the four breast cancer subtypes.