Comparison Of Anatomic Or Non-anatomic Hepatic Resection For Metachronous Colorectal Liver Metastasis

Objective: To explore the influence of anatomic and non anatomic hepatic resection on the prognosis of colorectal liver metastases(CLM).Methods: We retrospectively analyzed the complete medical records of 51 CLM underwent hepatic resection.Among the 51 patients,18 were received anatomic resection(AR),while other 33 were received non-anatomic resection(NAR).Two groups of patients were analyzed for survival curves that using Kaplan-Meier method and log-rank test.The COX regression model was employed to identify independent predictors for disease-free survival(DFS)and overall survival(OS).All statistical processing was performed by SPSS22.0(IBM)and a Pvalue<0.05 as the threshold of significance.Results: The 1-,3-and 5-year disease-free survival(DFS)were 72.2%、46.0% and 46.0% respectively in AR group and 69.7%、34.8% and 27.4%respectively in NAR group,there were no Significant differences between thetwo groups,(p=0.352),the 1-,3-and 5-year overall survival(OS)rates were83.3%、66.7% and 38.9% respectively in AR group and 81.8%、42.4%and27.3 % respectively in NAR group,no significant differences were found between the two groups(p = 0.213).Multivariate analysis identified surgical patterns was not as the independent risk factors of postoperative DFS and OS of these patients,and the time of liver metastases after the first surgurg,primary nodal status,tumor number,CEA level were independent prognostic risk factors for DFS,while primary nodal status and CEA levelwere independent prognostic factors for OS.Conclusions: Surgical patterns,including AR or NAR,didn’t affect the postoperative OS and DFS of CLM,Choices of AR or NAR are mainly according to the clinical characteristics of colorectal liver metastases and individualization of treatment.